Fig. 15
From: MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease
Analysis of LDLR and LRP1 levels in the cerebrovasculature and the soluble brain fraction. Levels of the A, B LDLR receptor and C, D LRP1 receptor were analyzed in the A, C soluble brain fraction and B, D the cerebrovasculature of wild type, 5xFAD, 5xFAD/MMP9KO, 5xFAD/MMP9KO-het and MMP9KO mice. Animals were approximately 6 months of age and values represent mean ± SEM (N = 12, 6 males, 6 females for each group). No statistically significant differences in LDLR or LRP1 levels were identified between any genotype in either brain fraction by ANOVA. LDLR Low-density lipoprotein receptor, LRP1 Low density lipoprotein receptor-related protein 1, FAD Familial Alzheimer’s disease, MMP Matrix metallopeptidase, MMP9KO MMP9 knockout, MMP9KO-het MMP9KO heterozygous, SEM Standard error of the mean, ANOVA Analysis of variance