Fig. 4
From: MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease
Spatial memory testing using the RAWM. SB-3CT and vehicle-treated E4FAD mice were tested for their ability to find the hidden platform in the RAWM. A A schematic of the maze layout is displayed. Mice were tested in nine trials per day for 5 days. B The number of incorrect entries made and C the time taken to find the maze were recorded and analyzed. D The total distance travelled per trial and E the average velocity while swimming was also evaluated. Animals were approximately 5 months of age and values represent mean ± SEM (N = 14, 5 males, 9 females for each group). No statistical significance was identified in any of the parameters by ANOVA. RAWM Radial arm water maze, E4FAD Apolipoprotein E4 x Familial Alzheimer’s disease, SEM Standard error of the mean, ANOVA Analysis of variance