Fig. 9

Anxiety-related behavior and locomotor activity in the OFT and the EPM. Wild type, 5xFAD, 5xFAD/MMP9KO and MMP9KO mice were tested using A, B, C the OFT and D, E, F, the EPM. A For the OFT, the duration spent in the outer, middle, and center areas of the circular arena was measured along with B the total distance travelled and C the average velocity. D For the EPM, the duration spent in the closed and open arms was measured together with E the total distance travelled and F the average velocity. Animals were approximately 6 months of age and values represent mean ± SEM (N = 12, 6 males, 6 females for each group). Statistical significance was determined by (A, D) ANOVA and (B, C, E, F) one-way ANOVA followed by the BKY procedure. *p < 0.05, **p < 0.01. OFT Open field test, EPM Elevated plus maze, WT Wild-type, MMP Matrix metallopeptidase, FAD Familial Alzheimer’s disease, MMP9KO MMP9 knockout, SEM Standard error of the mean, ANOVA Analysis of variance, BKY Benjamini, Krieger, and Yekutieli