Fig. 1From: Epileptiform activity in mouse hippocampal slices induced by moderate changes in extracellular Mg2+, Ca2+, and K+Hippocampal ictal discharges of thin slices. Traces collected from slices of young (A, B), middle-aged (D, C) or aged (E, F) mice. CA3 and CA1 field potentials recorded simultaneously during slice perfusion with moderately modified (m)ACSF. A Traces collected before and following high frequency stimulation (HFS, filled arrow) and illustrated after treatment with a band-pass filter (2–500 Hz). B A discharge event expanded in a wide frequency band (0–1000 Hz). Filled circles denoted preictal spikes. C–F Spontaneous or HFS-induced ictal discharges similarly illustrated as above. CA3 unit spikes expanded (E, insert). Note discharges with the hypersynchronous onset in B and D and discharges without an evident component of the hypersynchronous onset in FBack to article page