From: A systematic review of common genetic variation and biological pathways in autism spectrum disorder
Term | # | Genes | p-value | Bonferroni |
---|---|---|---|---|
Serotonergic synapse | 13 | HTR2A, HTR3A, CACNA1C, DDC, GABRB1, GABRB3, MAOA, MAOB, PLA2G4C, PTGS2, PRKCB, SLC6A4, TPH2 | 3.4 × 10−8 | 3.2 × 10−6 |
Neuroactive ligand-receptor interaction | 19 | HTR2A, ADRB2, AVPR1A, DRD1, DRD2, DRD3, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, GRIN2A, GRIN2B, GRIK2, GRIK5, GRM7, OXTR, VIPR2 | 3.6 × 10−8 | 3.2 × 10−6 |
Calcium signaling pathway | 14 | HTR2A, ATP2B2, ADRB2, AVPR1A, CACNA1C, CACNA1G, CHRNA7, DRD1, GRIN2A, NOS2, OXTR, PRKCB, SLC25A6 | 9.9 × 10−7 | 3.0 × 10−5 |
Dopaminergic synapse | 12 | CACNA1C, DDC, DRD1, DRD2, DRD3, GRIN2A, GRIN2B, MAOA, MAOB, PRKCB, PPP2R5D, SLC18A1 | 1.4 × 10−6 | 3.5 × 10−5 |
GABAergic synapse | 9 | ABAT, CACNA1C, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, PRKCB | 2.1 × 10−5 | 4.8 × 10−4 |
Glutamatergic synapse | 10 | SHANK2, SHANK3, CACNA1C, GRIN2A, GRIN2B, GRIK5, GRM7, HOMER1, PLA2G4C, PRKCB | 2.7 × 10−5 | 5.3 × 10−4 |
Retrograde endocannabinoid signaling | 9 | CACNA1C, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, PTGS2, PRKCB | 7.5 × 10−5 | 1.3 × 10−3 |
Tryptophan metabolism | 7 | ASMT, AADAT, DDC, MAOA, MAOB, TDO2 | 2.1 × 10−4 | 3.5 × 10−3 |