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Table 1 Results of the over-representation analysis using the KEGG Pathway database

From: A systematic review of common genetic variation and biological pathways in autism spectrum disorder

Term

#

Genes

p-value

Bonferroni

Serotonergic synapse

13

HTR2A, HTR3A, CACNA1C, DDC, GABRB1, GABRB3, MAOA, MAOB, PLA2G4C, PTGS2, PRKCB, SLC6A4, TPH2

3.4 × 10−8

3.2 × 10−6

Neuroactive ligand-receptor interaction

19

HTR2A, ADRB2, AVPR1A, DRD1, DRD2, DRD3, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, GRIN2A, GRIN2B, GRIK2, GRIK5, GRM7, OXTR, VIPR2

3.6 × 10−8

3.2 × 10−6

Calcium signaling pathway

14

HTR2A, ATP2B2, ADRB2, AVPR1A, CACNA1C, CACNA1G, CHRNA7, DRD1, GRIN2A, NOS2, OXTR, PRKCB, SLC25A6

9.9 × 10−7

3.0 × 10−5

Dopaminergic synapse

12

CACNA1C, DDC, DRD1, DRD2, DRD3, GRIN2A, GRIN2B, MAOA, MAOB, PRKCB, PPP2R5D, SLC18A1

1.4 × 10−6

3.5 × 10−5

GABAergic synapse

9

ABAT, CACNA1C, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, PRKCB

2.1 × 10−5

4.8 × 10−4

Glutamatergic synapse

10

SHANK2, SHANK3, CACNA1C, GRIN2A, GRIN2B, GRIK5, GRM7, HOMER1, PLA2G4C, PRKCB

2.7 × 10−5

5.3 × 10−4

Retrograde endocannabinoid signaling

9

CACNA1C, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, PTGS2, PRKCB

7.5 × 10−5

1.3 × 10−3

Tryptophan metabolism

7

ASMT, AADAT, DDC, MAOA, MAOB, TDO2

2.1 × 10−4

3.5 × 10−3

  1. Significant terms using Bonferroni correction are included. Other disease processes are not presented in this table
  2. KEGG Kyoto encyclopedia of genes and genomes, GABA γ-aminobutyric acid