Fig. 5

Euthyroid HT induces ultrastructure changes in frontal synapses. a Representative EM images of synapses (arrowheads). b Representative EM images of synaptic interface; V represents synaptic vesicles; the synaptic active zone is indicated by white arrows; SC represents the synaptic cleft; PSD is indicated by black arrowheads. c–h Quantitation of the synaptic interface, including synapse density (c), number of vesicles (d), active zone length (e), synaptic cleft (f), PSD thickness (g), and synaptic curvature (h). Data are the mean ± SEM (n = 4 mice/group); Scale bars: a = 500 nm; b = 200 nm