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Cellular and molecular mechanisms

In this section topics of interest include, but are not limited to, neurotransmitters, neurotransmission, gliotransmission, synaptic transmission, neuropsychopharmacology, cell signaling, neurophysiology, neurogenetics and neurogenomics.

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  1. Autism, a childhood behavioral disorder, belongs to a large suite of diseases, collectively referred to as autism spectrum disorders (ASD). Though multifactorial in etiology, approximately 10% of ASD are assoc...

    Authors: Kyong-Oh Shin, Debra A. Crumrine, Sungeun Kim, Yerin Lee, Bogyeong Kim, Katrina Abuabara, Chaehyeong Park, Yoshikazu Uchida, Joan S. Wakefield, Jason M. Meyer, Sekyoo Jeong, Byeong Deog Park, Kyungho Park and Peter M. Elias

    Citation: BMC Neuroscience 2021 22:43

    Content type: Research article

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  2. The receptor for advanced glycation end-products (RAGE) is involved in neuroinflammation. This study investigated the changes in RAGE expression following noise-induced hearing loss.

    Authors: Chang Ho Lee, Kyung Woon Kim, Da-hye Lee, So Min Lee and So Young Kim

    Citation: BMC Neuroscience 2021 22:38

    Content type: Research article

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  3. Nociceptin/orphanin FQ (N/OFQ) has been revealed to play bidirectional roles in orofacial pain modulation. Calcitonin gene-related peptide (CGRP) is a well-known pro-nociceptive molecule that participates in t...

    Authors: Xinyu Yan, Han Han, Shizhen Zhang, Yanzhu Lu, Linghuan Ren, Yufei Tang, Xiaolong Li, Fan Jian, Yan Wang, Hu Long and Wenli Lai

    Citation: BMC Neuroscience 2021 22:25

    Content type: Research article

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  4. Hepatic encephalopathy (HE) is a neurological complication resulting from acute or chronic liver disease. Hyperammonemia leading to astrocyte swelling and cerebral edema in combination with neuroinflammation i...

    Authors: Fatme Seval Ismail, Timo Jendrik Faustmann, Franco Corvace, Anamariya Tsvetanova, Zahra Moinfar and Pedro M. Faustmann

    Citation: BMC Neuroscience 2021 22:21

    Content type: Research article

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  5. The Period Circadian Regulator 2 (Per2) gene is important for the modulation of circadian rhythms that influence biological processes. Circadian control of the hypothalamus-pituitary-adrenal (HPA) axis is critica...

    Authors: Ashley L. Russell, Lauren Miller, Hannah Yi, Rita Keil, Robert J. Handa and T. John Wu

    Citation: BMC Neuroscience 2021 22:5

    Content type: Research article

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  6. Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurologic...

    Authors: Emilia Zgórzyńska, Dawid Stulczewski, Barbara Dziedzic, Kuan-Pin Su and Anna Walczewska

    Citation: BMC Neuroscience 2021 22:4

    Content type: Research article

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  8. Glucose fluctuation promotes neuronal apoptosis, which plays a central role in diabetic encephalopathy (DE). Nerve growth factor (NGF), and its interaction with high-affinity (TrkA) and low-affinity (p75NTR) r...

    Authors: Ting Yan, Zhihui Zhang and Danqing Li

    Citation: BMC Neuroscience 2020 21:38

    Content type: Research article

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  9. Neonatal hypoxic-ischemic encephalopathy (HIE) represents as a major cause of neonatal morbidity and mortality. However, the underlying molecular mechanisms in brain damage are still not fully elucidated. This...

    Authors: Ya Jiang, Xue Bai, Ting-Ting Li, Mohammed AL-Hawwas, Yuan Jin, Yu Zou, Yue Hu, Lin-Yi Liu, Ying Zhang, Qing Liu, Hao Yang, Jun Ma, Ting-Hua Wang, Jia Liu and Liu-Lin Xiong

    Citation: BMC Neuroscience 2020 21:18

    Content type: Research article

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  10. Histone deacetylase-3 (HDAC3) promotes neurodegeneration in various cell culture and in vivo models of neurodegeneration but the mechanism by which HDAC3 exerts neurotoxicity is not known. HDAC3 is known to be...

    Authors: Anto Sam Crosslee Louis Sam Titus, Dharmendra Sharma, Min Soo Kim and Santosh R. D’Mello

    Citation: BMC Neuroscience 2019 20:65

    Content type: Research article

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  11. Infection is an important clinical complication facing stroke-patients and triples the risk of death within 30 days post-stroke via mechanisms which are poorly understood.

    Authors: Ping Wang, Jiaqi Zhang, Feifei Guo, Shuang Wang, Yi Zhang, Defeng Li, Haiyu Xu and Hongjun Yang

    Citation: BMC Neuroscience 2019 20:64

    Content type: Research article

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  13. The pharmacodynamic results of diazepam and ethanol administration are similar, in that each can mediate amnestic and sedative-hypnotic effects. Although each of these molecules effectively reduce the activity...

    Authors: Matthias Kreuzer, Paul S. García, Verena Brucklacher-Waldert, Rebecca Claassen, Gerhard Schneider, Bernd Antkowiak and Berthold Drexler

    Citation: BMC Neuroscience 2019 20:58

    Content type: Research article

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  14. Mammalian Shc (Src homology and collagen) proteins comprise a family of four phosphotyrosine adaptor molecules which exhibit varied spatiotemporal expression and signaling functions. ShcD is the most recently ...

    Authors: Hannah N. Robeson, Hayley R. Lau, Laura A. New, Jasmin Lalonde, John N. Armstrong and Nina Jones

    Citation: BMC Neuroscience 2019 20:57

    Content type: Research article

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  15. Neuroactive steroids seem to be implicated in a variety of neurophysiological and behavioral processes, such as sleep, learning, memory, stress, feeding and aging. Numerous studies have also addressed this imp...

    Authors: Jan Martin, Eva Plank, Bettina Jungwirth, Alexander Hapfelmeier, Armin Podtschaske and Simone M. Kagerbauer

    Citation: BMC Neuroscience 2019 20:53

    Content type: Research article

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  16. Traumatic brain injury (TBI) is a widespread public health problem and a signature injury of our military in modern conflicts. Despite the long-term effects of even mild brain injuries, an effective treatment ...

    Authors: Whitney A. Ratliff, Jessica N. Saykally, Ronald F. Mervis, Xiaoyang Lin, Chuanhai Cao and Bruce A. Citron

    Citation: BMC Neuroscience 2019 20:44

    Content type: Research article

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  17. Parkinson's disease is a progressive degenerative nervous system disease. Recent studies have shown that secondary changes in the GABA system play directly affect the pathogenesis of PD. There is still much de...

    Authors: Lixuan Huang, Yande Ren, Zisan Zeng, Hao Ren, Shaojun Li, Shengnan He, Fan He and Xiangrong Li

    Citation: BMC Neuroscience 2019 20:42

    Content type: Research article

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  18. The functional heterogeneity of the hippocampus along its longitudinal axis at the level of behavior is an established concept; however, the neurobiological mechanisms are still unknown. Diversifications in th...

    Authors: Andriana Koutsoumpa and Costas Papatheodoropoulos

    Citation: BMC Neuroscience 2019 20:35

    Content type: Research article

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  19. Brain iron is an essential as well as a toxic redox active element. Physiological levels are not uniform among the different cell types. Besides the availability of quantitative methods, the knowledge about th...

    Authors: Anja Reinert, Markus Morawski, Johannes Seeger, Thomas Arendt and Tilo Reinert

    Citation: BMC Neuroscience 2019 20:25

    Content type: Research article

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  21. To determine whether photobiomodulation (PBM) rescued the disruption of Na+/Ca2+ homeostasis and mitochondrial membrane potential by ouabain; the Na, K-ATPase inhibitor. For PBM in this study, a 660 nm LED array ...

    Authors: Yun-Hee Rhee, Jeong Hwan Moon, Jae Yun Jung, Connie Oh, Jin-Chul Ahn and Phil-Sang Chung

    Citation: BMC Neuroscience 2019 20:19

    Content type: Research article

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  22. Smoking (TS) and recently e-cigarettes (EC) vaping, have been associated with vascular endothelial dysfunction primarily relevant to oxidative stress, exposure to nicotine, and smoking-induced inflammation. It...

    Authors: Farzane Sivandzade and Luca Cucullo

    Citation: BMC Neuroscience 2019 20:15

    Content type: Research article

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  23. Global cerebral ischemia triggers neurodegeneration in the hippocampal CA1 region, but the mechanism of neuronal death remains elusive. The epsilon isoform of protein kinase C (PKCε) has recently been identifi...

    Authors: Varun Kumar, Yi-Chinn Weng, Yu-Chieh Wu, Yu-Ting Huang and Wen-Hai Chou

    Citation: BMC Neuroscience 2018 19:76

    Content type: Research article

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  24. The plasma membrane Na+/Ca2+-exchanger (NCX) has recently been shown to regulate Ca2+-dependent N-methyl-d-aspartate receptor (NMDAR) desensitization, suggesting a tight interaction of NCXs and NMDARs in lipid na...

    Authors: Dmitry A. Sibarov, Ekaterina E. Poguzhelskaya and Sergei M. Antonov

    Citation: BMC Neuroscience 2018 19:73

    Content type: Research article

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  25. Minocycline is a lipophilic tetracycline of increasing appeal in neuroscience as it inhibits microglial activation, a mechanism involved in numerous neuropsychiatric disorders. Own data point towards retinoid-...

    Authors: Vera Clemens, Francesca Regen, Nathalie Le Bret, Isabella Heuser and Julian Hellmann-Regen

    Citation: BMC Neuroscience 2018 19:58

    Content type: Research article

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  26. The long-term effects of psychotropic drugs are associated with the reversal of disease-related alterations through the reorganization and normalization of neuronal connections. Molecular factors that trigger ...

    Authors: Magdalena Zygmunt, Dżesika Hoinkis, Jacek Hajto, Marcin Piechota, Bożena Skupień-Rabian, Urszula Jankowska, Sylwia Kędracka-Krok, Jan Rodriguez Parkitna and Michał Korostyński

    Citation: BMC Neuroscience 2018 19:55

    Content type: Research article

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  28. Adipose tissue is a dynamic organ with different effects on the body. Many of these effects are mediated by leptin, a hormone strongly involved in regulation of feeding and energy metabolism. It has an importa...

    Authors: Laura Mora-Muñoz, Alejandro Guerrero-Naranjo, Elisa Angélica Rodríguez-Jimenez, Claudio Alberto Mastronardi and Alberto Velez-van-Meerbeke

    Citation: BMC Neuroscience 2018 19:51

    Content type: Review

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  29. The amino acid taurine (2-Aminoethanesulfonic acid) modulates inhibitory neurotransmitter receptors. This study aimed to determine if the dual action of taurine on GABAC-ρ1R relates to its structure. To address t...

    Authors: Lenin David Ochoa-de la Paz, Martin González-Andrade, Herminia Pasantes-Morales, Rodrigo Franco, Rubén Zamora-Alvarado, Edgar Zenteno, Hugo Quiroz-Mercado, Roberto Gonzales-Salinas and Rosario Gulias-Cañizo

    Citation: BMC Neuroscience 2018 19:47

    Content type: Research article

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  30. Light exposure induces oxidative stress, which contributes to ocular diseases of aging. Blue light provides a model for light-induced oxidative stress, lipid peroxidation and retinal degeneration in Drosophila me...

    Authors: Hana Hall, Jingqun Ma, Sudhanshu Shekhar, Walter D. Leon-Salas and Vikki M. Weake

    Citation: BMC Neuroscience 2018 19:43

    Content type: Research article

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  31. Striatal fast-spiking interneurons (FSI) are a subset of GABAergic cells that express calcium-binding protein parvalbumin (PV). They provide feed-forward inhibition to striatal projection neurons (SPNs), recei...

    Authors: Ernesto Alberto Rendón-Ochoa, Teresa Hernández-Flores, Victor Hugo Avilés-Rosas, Verónica Alejandra Cáceres-Chávez, Mariana Duhne, Antonio Laville, Dagoberto Tapia, Elvira Galarraga and José Bargas

    Citation: BMC Neuroscience 2018 19:42

    Content type: Research article

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  32. Many neuropsychiatric disorders develop in early life. Although the mechanisms involved have not been elucidated, it is possible that functional abnormalities of parvalbumin-positive interneurons (PV neurons) ...

    Authors: Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Shozo Aoki and Takeshi Ishihara

    Citation: BMC Neuroscience 2018 19:41

    Content type: Research article

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  34. Accumulation of the α-synuclein (α-syn) protein is a hallmark of a group of brain disorders collectively known as synucleinopathies. The mechanisms responsible for α-syn accumulation are not well understood. S...

    Authors: Jared Schommer, Gurdeep Marwarha, Trevor Schommer, Travis Flick, Jonah Lund and Othman Ghribi

    Citation: BMC Neuroscience 2018 19:17

    Content type: Research article

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  35. Chronic opioid therapy for non-malignant pain conditions has significantly increased over the last 15 years. Recently, the correlation between opioid analgesics and alternations in brain structure, such as leu...

    Authors: Ruping Fan, Lisa M. Schrott, Thomas Arnold, Stephen Snelling, Meghana Rao, Derrel Graham, Angela Cornelius and Nadejda L. Korneeva

    Citation: BMC Neuroscience 2018 19:15

    Content type: Research article

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  36. Sleep deprivation impairs learning, causes stress, and can lead to death. Notch and JNK-1 pathways impact C. elegans sleep in complex ways; these have been hypothesized to involve compensatory sleep. C. elegans D...

    Authors: Heather L. Bennett, Yulia Khoruzhik, Dustin Hayden, Huiyan Huang, Jarred Sanders, Melissa B. Walsh, David Biron and Anne C. Hart

    Citation: BMC Neuroscience 2018 19:10

    Content type: Research article

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  38. Intracellular calcium is an important ion involved in the regulation and modulation of many neuronal functions. From regulating cell cycle and proliferation to initiating signaling cascades and regulating pres...

    Authors: Elena Artimovich, Russell K. Jackson, Michaela B. C. Kilander, Yu-Chih Lin and Michael W. Nestor

    Citation: BMC Neuroscience 2017 18:72

    Content type: Software

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  39. A sensitive, rapid and selective UHPLC–MS/MS method has been developed and validated for the quantification of Nicotine (NT) and Cotinine (CN) using Continine-d 3 as internal standard (...

    Authors: Mohammad A. Kaisar, Raja Reddy Kallem, Ravi K. Sajja, Ali Ehsan Sifat and Luca Cucullo

    Citation: BMC Neuroscience 2017 18:71

    Content type: Methodology

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  40. Alzheimer’s disease is characterized by the accumulation of amyloid beta (Aβ) and the formation of neurofibrillary tangles. Aβ is the main constituent of senile plaques and is largely involved in neuronal deat...

    Authors: Yuqin Zhang, Changchun Chen, Yanliu Jiang, Shupei Wang, Xiaoyu Wu and Kai Wang

    Citation: BMC Neuroscience 2017 18:69

    Content type: Research article

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  41. The Na+/K+-ATPases are transmembrane ion pumps important for maintenance of ion gradients across the plasma membrane that serve to support multiple cellular functions, such as membrane potentials, regulation of c...

    Authors: Ditte Gry Ellman, Toke Jost Isaksen, Minna Christiansen Lund, Safinaz Dursun, Martin Wirenfeldt, Louise Helskov Jørgensen, Karin Lykke-Hartmann and Kate Lykke Lambertsen

    Citation: BMC Neuroscience 2017 18:66

    Content type: Research article

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  42. CLCA is a family of metalloproteases that regulate Ca2+-activated Cl− fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an endogenous Anoctamin 1 (ANO1, also termed TMEM16A)-dep...

    Authors: Casilda V. Mura, Ricardo Delgado, María Graciela Delgado, Diego Restrepo and Juan Bacigalupo

    Citation: BMC Neuroscience 2017 18:61

    Content type: Research article

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  43. The identification of biomarkers that predict susceptibility to major depressive disorder and treatment response to antidepressants is a major challenge. Vortioxetine is a novel multimodal antidepressant that ...

    Authors: Jessica A. Waller, Sara Holm Nygaard, Yan Li, Kristian Gaarn du Jardin, Joseph A. Tamm, Aicha Abdourahman, Betina Elfving, Alan L. Pehrson, Connie Sánchez and Rasmus Wernersson

    Citation: BMC Neuroscience 2017 18:56

    Content type: Research article

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  44. CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron...

    Authors: Hiroto Tsunematsu, Akiko Uyeda, Nobuhiko Yamamoto and Noriyuki Sugo

    Citation: BMC Neuroscience 2017 18:55

    Content type: Methodology article

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  45. In the recent decade, iron oxide nanoparticles (IONPs) have been proposed for several applications in the central nervous system (CNS), including targeting amyloid beta (Aβ) in the arteries, inhibiting the mic...

    Authors: Zahra Yarjanli, Kamran Ghaedi, Abolghasem Esmaeili, Soheila Rahgozar and Ali Zarrabi

    Citation: BMC Neuroscience 2017 18:51

    Content type: Review

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  46. The GluN2B subunit of the N-methyl-d-aspartate receptor (NMDAr) modulates many physiological processes including learning, memory, and pain. Excessive increase in NMDAr/GluN2B activity has been associated with va...

    Authors: Edwin A. Reyes-Guzman, Nohora Vega-Castro, Edgar A. Reyes-Montaño and Esperanza Recio-Pinto

    Citation: BMC Neuroscience 2017 18:44

    Content type: Research article

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  47. Recent studies have suggested that the activation of mammalian target of rapamycin (mTOR) signaling may be related to antidepressant action. Therefore, the present study evaluated whether antidepressant drugs ...

    Authors: Mi Kyoung Seo, Cheol Min Choi, Roger S. McIntyre, Hye Yeon Cho, Chan Hong Lee, Rodrigo B. Mansur, Yena Lee, Jae-Hon Lee, Young Hoon Kim, Sung Woo Park and Jung Goo Lee

    Citation: BMC Neuroscience 2017 18:39

    Content type: Research article

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  48. The mechanisms of steroids actions in the brain mainly involve the binding and nuclear translocation of specific cytoplasmic receptors. These receptors can act as transcription factors and regulate gene expres...

    Authors: Marcin Piechota, Michał Korostynski, Slawomir Golda, Joanna Ficek, Danuta Jantas, Ziolkowska Barbara and Ryszard Przewlocki

    Citation: BMC Neuroscience 2017 18:37

    Content type: Research article

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  49. Cation-chloride cotransporters (CCCs) are indispensable for maintaining chloride homeostasis in multiple cell types, but K–Cl cotransporter KCC2 is the only CCC member with an exclusively neuronal expression i...

    Authors: Anastasia Ludwig, Claudio Rivera and Pavel Uvarov

    Citation: BMC Neuroscience 2017 18:23

    Content type: Methodology

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  50. Previous studies have indicated that selenium supplementation may be beneficial in neuroprotection against glutamate-induced cell damage, in which mitochondrial dysfunction is considered a major pathogenic fea...

    Authors: Yan-Mei Ma, Gordon Ibeanu, Li-Yao Wang, Jian-Zhong Zhang, Yue Chang, Jian-Da Dong, P. Andy Li and Li Jing

    Citation: BMC Neuroscience 2017 18:15

    Content type: Research article

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