Articles

Iron deposition in Parkinson’s disease by quantitative susceptibility mapping

Patients with Parkinson’s disease (PD) have elevated levels of brain iron, especially in the nigrostriatal dopaminergic system. The purpose of this study was to evaluate the iron deposition in the substantia n...

Authors: Qiqi Chen, Yiting Chen, Yue Zhang, Furu Wang, Hongchang Yu, Caiyuan Zhang, Zhen Jiang and Weifeng Luo

In vitro characterization of odorranalectin for peptide-based drug delivery across the blood–brain barrier

The use of siRNA-based gene silencing has been recently underscored as a potential therapeutic strategy for the treatment of neurological disorders. However, the stability of siRNA and other small molecule the...

Authors: Ravi K. Sajja, Predrag Cudic and Luca Cucullo

Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration

The dorsal root ganglia (DRG) are a critical component of the peripheral nervous system, and function to relay somatosensory information from the body’s periphery to sensory perception centres within the brain...

Authors: Sophie Wiszniak and Quenten Schwarz

Electric stimulation of the medial forebrain bundle influences sensorimotor gaiting in humans

Prepulse inhibition (PPI) of the acoustic startle response, a measurement of sensorimotor gaiting, is modulated by monoaminergic, presumably dopaminergic neurotransmission. Disturbances of the dopaminergic sys...

Authors: Patricia Panther, Maria Kuehne, Jürgen Voges, Sven Nullmeier, Jörn Kaufmann, Janet Hausmann, Daniel Bittner, Imke Galazky, Hans-Jochen Heinze, Andreas Kupsch and Tino Zaehle

Effect of photobiomodulation therapy on neuronal injuries by ouabain: the regulation of Na, K-ATPase; Src; and mitogen-activated protein kinase signaling pathway

To determine whether photobiomodulation (PBM) rescued the disruption of Na⁺/Ca²⁺ homeostasis and mitochondrial membrane potential by ouabain; the Na, K-ATPase inhibitor. For PBM in this study, a 660 nm LED array ...

Authors: Yun-Hee Rhee, Jeong Hwan Moon, Jae Yun Jung, Connie Oh, Jin-Chul Ahn and Phil-Sang Chung

Subclinical lipopolysaccharide from Salmonella Enteritidis induces neuropeptide dysregulation in the spinal cord and the dorsal root ganglia

Despite increasing evidence that lipopolysaccharide (LPS) affects the biological active substances of dorsal root ganglia (DRG) we have limited knowledge of the influence of a single low dose of LPS, which doe...

Authors: Anita Mikołajczyk and Dagmara Złotkowska

Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain

Reports show that stressful events before injury exacerbates post-injury pain. The mechanism underlying stress-induced heightened thermal pain is unclear. Here, we examined the effects of chronic intermittent ...

Authors: Natasha M. Sosanya, Thomas H. Garza, Winfred Stacey, Stephen L. Crimmins, Robert J. Christy and Bopaiah P. Cheppudira

Affective and cognitive behavior is not altered by chronic constriction injury in B7-H1 deficient and wildtype mice

Chronic neuropathic pain is often associated with anxiety, depressive symptoms, and cognitive impairment with relevant impact on patients` health related quality of life. To investigate the influence of a pro-...

Authors: Franziska Karl, Maria B. Nandini Colaço, Annemarie Schulte, Claudia Sommer and Nurcan Üçeyler

Assessing the protective effect of rosiglitazone against electronic cigarette/tobacco smoke-induced blood–brain barrier impairment

Smoking (TS) and recently e-cigarettes (EC) vaping, have been associated with vascular endothelial dysfunction primarily relevant to oxidative stress, exposure to nicotine, and smoking-induced inflammation. It...

Authors: Farzane Sivandzade and Luca Cucullo

Additive effect of 5-HT2C and CB1 receptor blockade on the regulation of sleep–wake cycle

Previous data show that serotonin 2C (5-HT_2C) and cannabinoid 1 (CB₁) receptors have a role in the modulation of sleep–wake cycle. Namely, antagonists on these receptors promoted wakefulness and inhibited rapid e...

Authors: Emese Bogáthy, Noémi Papp, Laszló Tóthfalusi, Szilvia Vas and György Bagdy

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease

Knock-in (KI) mouse models of Alzheimer’s disease (AD) that endogenously overproduce Aβ without non-physiological overexpression of amyloid precursor protein (APP) provide important insights into the pathogeni...

Authors: Yasufumi Sakakibara, Michiko Sekiya, Takashi Saito, Takaomi C. Saido and Koichi M. Iijima

Non-invasive measurement of hemodynamic change during 8 MHz transcranial focused ultrasound stimulation using near-infrared spectroscopy

Transcranial focused ultrasound (tFUS) attracts wide attention in neuroscience as an effective noninvasive approach to modulate brain circuits. In spite of this, the effects of tFUS on the brain is still uncle...

Authors: Evgenii Kim, Eloise Anguluan, Sangyeon Youn, Jihun Kim, Jae Youn Hwang and Jae Gwan Kim

Pretreatment with a CRF antagonist amplifies feeding inhibition induced by fourth ventricular cocaine- and amphetamine-regulated transcript peptide

Pre-treatment with the corticotropin-releasing factor antagonist α-helical CRF9-41 prevents inhibition of gastric emptying by cocaine-and amphetamine-regulated transcript peptide at a dorsal hindbrain level, b...

Authors: Ulrika Smedh, Karen A. Scott and Timothy H. Moran

Effect of lesion proximity on the regenerative response of long descending propriospinal neurons after spinal transection injury

The spinal cord is limited in its capacity to repair after damage caused by injury or disease. However, propriospinal (PS) neurons in the spinal cord have demonstrated a propensity for axonal regeneration afte...

Authors: Kristen Swieck, Amanda Conta-Steencken, Frank A. Middleton, Justin R. Siebert, Donna J. Osterhout and Dennis J. Stelzner

The short-term recovery of corticomotor responses in elbow flexors

The recovery of neurophysiological parameters at various time intervals following fatiguing exercise has been investigated previously. However, the repetition of neuromuscular assessments during the recovery p...

Authors: Saied Jalal Aboodarda, Selina Fan, Kyla Coates and Guillaume Y. Millet

Enhanced setup for wired continuous long-term EEG monitoring in juvenile and adult rats: application for epilepsy and other disorders

The electroencephalogram (EEG) is a widely used laboratory technique in rodent models of epilepsy, traumatic brain injury (TBI), and other neurological diseases accompanied by seizures. Obtaining prolonged con...

Authors: Yasser Medlej, Rita Asdikian, Lara Wadi, Houssein Salah, Laura Dosh, Rabih Hashash, Nabil Karnib, Mohammad Medlej, Hala Darwish, Firas Kobeissy and Makram Obeid

Exercise challenge alters Default Mode Network dynamics in Gulf War Illness

Gulf War Illness (GWI) affects 30% of veterans from the 1991 Gulf War and has no known cause. Everyday symptoms include pain, fatigue, migraines, and dyscognition. A striking syndromic feature is post-exertion...

Authors: Rakib U. Rayhan, Stuart D. Washington, Richard Garner, Kristina Zajur, Florencia Martinez Addiego, John W. VanMeter and James N. Baraniuk

Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of β-amyloid found in Alzheimer disease

Epidemiologic studies strongly suggest that the pathophysiology of late-onset Alzheimer disease (AD) versus early-onset AD has environmental rather than genetic causes, thus revealing potentially novel therape...

Authors: Zein Al-Atrache, Danielle B. Lopez, Susan T. Hingley and Denah M. Appelt

Time dependent degeneration of the nigrostriatal tract in mice with 6-OHDA lesioned medial forebrain bundle and the effect of activin A on l-Dopa induced dyskinesia

Accurately assessing promising therapeutic interventions for human diseases depends, in part, on the reproducibility of preclinical disease models. With the development of transgenic mice, the rapid adaptation...

Authors: Peggy Rentsch, Sandy Stayte, Gary P. Morris and Bryce Vissel

Correction to: Computing reward prediction errors and learning valence in the insect mushroom body

Following the publication of the original article [1], it was highlighted that an old version of the text for abstract P252 was published, thereby causing the text to no longer correspond with Fig. 1.

Authors: James Bennett and Thomas Nowotny

Inhibitory effect of ultrasonic stimulation on the voltage-dependent potassium currents in rat hippocampal CA1 neurons

Transcranial ultrasonic stimulation is a novel noninvasive tool for neuromodulation, and has high spatial resolution and deep penetration. Although it can increase excitation of neurons, its effects on neuron ...

Authors: Kun Cui, Shuai Zhang, Jinyao Sun, Xueying Zhang, Chong Ding and Guizhi Xu

The modulation effect of non-invasive brain stimulation on cognitive function in patients with mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials

To prevent and control dementia, many scholars have focused on the transition stage between normal ageing and dementia, mild cognitive impairment (MCI) which is a key interventional target for dementia. Studie...

Authors: Ying Xu, Zhijie Qiu, Jingfang Zhu, Jiao Liu, Jingsong Wu, Jing Tao and Lidian Chen

Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats

Peripheral diabetic neuropathy can be painful and its symptoms include hyperalgesia, allodynia and spontaneous pain. Hydrogen sulfide (H₂S) is involved in diabetes-induced hyperalgesia and allodynia. However, the...

Authors: José Eduardo Roa-Coria, Jorge Baruch Pineda-Farias, Paulino Barragán-Iglesias, Geovanna Nallely Quiñonez-Bastidas, Ángel Zúñiga-Romero, Juan Carlos Huerta-Cruz, Juan Gerardo Reyes-García, Francisco Javier Flores-Murrieta, Vinicio Granados-Soto and Héctor Isaac Rocha-González

Rapamycin treatment increases hippocampal cell viability in an mTOR-independent manner during exposure to hypoxia mimetic, cobalt chloride

Cobalt chloride (CoCl₂) induces chemical hypoxia through activation of hypoxia-inducible factor-1 alpha (HIF-1α). Mammalian target of rapamycin (mTOR) is a multifaceted protein capable of regulating cell growth, ...

Authors: Mary A. Zimmerman, Christan D. Biggers and P. Andy Li

Thrombin contributes to the injury development and neurological deficit after acute subdural hemorrhage in rats only in collaboration with additional blood-derived factors

Acute subdural hemorrhage (ASDH) is a severe consequence of traumatic brain injury. The occurrence of subdural blood increases the lethality of these patients independent of the amount of blood or elevated int...

Authors: Tobias J. Krämer, Wasim Sakas, Daniel Jussen, Harald Krenzlin, Oliver Kempski and Beat Alessandri

Offline encoding impaired by epigenetic regulations of monoamines in the guided propagation model of autism

Environmental factors can modify the expression of genes, including those involved in the metabolism of neurotransmitters. Accounting for a control role of monoamine neurotransmitters, the guided propagation (GP...

Authors: Dominique G. Béroule

Altered Slc25 family gene expression as markers of mitochondrial dysfunction in brain regions under experimental mixed anxiety/depression-like disorder

Development of anxiety- and depression-like states under chronic social defeat stress in mice has been shown by many experimental studies. In this article, the differentially expressed Slc25* family genes encodin...

Authors: Vladimir N. Babenko, Dmitry A. Smagin, Anna G. Galyamina, Irina L. Kovalenko and Natalia N. Kudryavtseva

The effect of anesthetic dose on the motor response induced by low-intensity pulsed ultrasound stimulation

Low-intensity pulsed ultrasound stimulation (LIPUS) has been proven to be a noninvasive method with high spatial resolution and deep penetration. Previous studies have qualitatively demonstrated that the elect...

Authors: Yi Yuan, Xingran Wang, Jiaqing Yan and Xiaoli Li

Dyskinesia and brain-derived neurotrophic factor levels after long-term levodopa and nicotinic receptor agonist treatments in female mice with near-total unilateral dopaminergic denervation

The treatment of Parkinson’s disease is often complicated by levodopa-induced dyskinesia (LID). Nicotinic acetylcholine receptor agonists can alleviate LID in animal models but may be less effective in conditi...

Authors: Sakari Leino, Samuel Kohtala, Tomi Rantamäki, Sini K. Koski, Saara Rannanpää and Outi Salminen

PKCε phosphorylation regulates the mitochondrial translocation of ATF2 in ischemia-induced neurodegeneration

Global cerebral ischemia triggers neurodegeneration in the hippocampal CA1 region, but the mechanism of neuronal death remains elusive. The epsilon isoform of protein kinase C (PKCε) has recently been identifi...

Authors: Varun Kumar, Yi-Chinn Weng, Yu-Chieh Wu, Yu-Ting Huang and Wen-Hai Chou

Metabolite differences between glutamate carboxypeptidase II gene knockout mice and their wild-type littermates after traumatic brain injury: a 7-tesla ¹H-MRS study

Traumatic brain injury (TBI) is a complex condition and remains a prominent public and medical health issue in individuals of all ages. A rapid increase in extracellular glutamate occurs after TBI, leading to ...

Authors: Wenbo Wu, Siyi Xu, Jialin Wang, Kuiming Zhang, Mingkun Zhang, Yang Cao, Hongqing Ren, Deyou Zheng and Chunlong Zhong

Biaryl scaffold-focused virtual screening for anti-aggregatory and neuroprotective effects in Alzheimer’s disease

Alzheimer’s disease (AD) is a primary cause of dementia in ageing population affecting more than 35 million people around the globe. It is a chronic neurodegenerative disease caused by defected folding and agg...

Authors: Sidra Khalid, Muhammad Ammar Zahid, Hussain Ali, Yeong S. Kim and Salman Khan

Abstracts of the 6th Meeting of the Neapolitan Brain Group

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Downregulation of calcium-dependent NMDA receptor desensitization by sodium-calcium exchangers: a role of membrane cholesterol

The plasma membrane Na⁺/Ca²⁺-exchanger (NCX) has recently been shown to regulate Ca²⁺-dependent N-methyl-d-aspartate receptor (NMDAR) desensitization, suggesting a tight interaction of NCXs and NMDARs in lipid na...

Authors: Dmitry A. Sibarov, Ekaterina E. Poguzhelskaya and Sergei M. Antonov

Glycine receptors expression in rat spinal cord and dorsal root ganglion in prostaglandin E2 intrathecal injection models

Glycine receptors (GlyRs) are involved in the development of spinal pain sensitization. The GlyRα3 subunit has recently emerged as a key factor in inflammatory pain pathways in the spinal cord dorsal horn (DH)...

Authors: Hung-Chen Wang, Kuang-I Cheng, Pei-Ru Chen, Kuang-Yi Tseng, Aij-Lie Kwan and Lin-Li Chang

Riboflavin and pyridoxine restore dopamine levels and reduce oxidative stress in brain of rats

Neurological disorders suggest that the excitotoxicity involves a drastic increase in intracellular Ca²⁺ concentrations and the formation of reactive oxygen species. The presence of these free radicals may also a...

Authors: Armando Valenzuela Peraza, David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortiz Herrera, Hugo Juárez Olguín, Miroslava Lindoro Silva, Belén Juárez Tapia and Gerardo Barragán Mejía

PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity

The proteasome system plays an important role in synaptic plasticity. Induction and maintenance of long term potentiation is directly dependent on selective targeting of proteins for proteasomal degradation. T...

Authors: Julia Adelöf, My Andersson, Michelle Porritt, Anne Petersen, Madeleine Zetterberg, John Wiseman and Malin Hernebring

Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization

FoxP transcription factors play crucial roles for the development and function of vertebrate brains. In humans the neurally expressed FOXPs, FOXP1, FOXP2, and FOXP4 are implicated in cognition, including langu...

Authors: Adriana Schatton, Julia Agoro, Janis Mardink, Gérard Leboulle and Constance Scharff

The significance of anti-neuronal antibodies for acute psychiatric disorders: a retrospective case–controlled study

The clinical significance of anti-neuronal antibodies in patients with psychiatric disorders, but without encephalitis, remains unknown. In patients admitted to acute psychiatric inpatient care we aimed to ide...

Authors: Morten B. Schou, Sverre Georg Sæther, Ole Kristian Drange, Karoline Krane-Gartiser, Solveig K. Reitan, Arne E. Vaaler and Daniel Kondziella

27th Annual Computational Neuroscience Meeting (CNS*2018): Part Two

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27th Annual Computational Neuroscience Meeting (CNS*2018): Part One

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Transcranial direct current stimulation for the treatment of tinnitus: a review of clinical trials and mechanisms of action

Tinnitus is the perception of sound in the absence of any external acoustic stimulation. Transcranial direct current stimulation (tDCS) has shown promising though heterogeneous therapeutic outcomes for tinnitu...

Authors: Tifei Yuan, Ali Yadollahpour, Julio Salgado-Ramírez, Daniel Robles-Camarillo and Rocío Ortega-Palacios

Functional EEG connectivity during competition

Social behavior and interactions pervasively shape and influence our lives and relationships. Competition, in particular, has become a core topic in social neuroscience since it stresses the relevance and sali...

Authors: Michela Balconi and Maria Elide Vanutelli

Neurovascular dysfunction in vascular dementia, Alzheimer’s and atherosclerosis

Efficient blood supply to the brain is of paramount importance to its normal functioning and improper blood flow can result in potentially devastating neurological consequences. Cerebral blood flow in response...

Authors: Osman Shabir, Jason Berwick and Sheila E. Francis

Social defeat stress before pregnancy induces depressive-like behaviours and cognitive deficits in adult male offspring: correlation with neurobiological changes

Epidemiological surveys and studies with animal models have established a relationship between maternal stress and affective disorders in their offspring. However, whether maternal depression before pregnancy ...

Authors: Sheng Wei, Zifa Li, Meng Ren, Jieqiong Wang, Jie Gao, Yinghui Guo, Kaiyong Xu, Fang Li, Dehao Zhu, Hao Zhang, Rongju Lv and Mingqi Qiao

Effect of pulsed transcranial ultrasound stimulation at different number of tone-burst on cortico-muscular coupling

Pulsed transcranial ultrasound stimulation (pTUS) can modulate the neuronal activity of motor cortex and elicit muscle contractions. Cortico-muscular coupling (CMC) can serve as a tool to identify interaction ...

Authors: Ping Xie, Sa Zhou, Xingran Wang, Yibo Wang and Yi Yuan

An effort toward molecular biology of food deprivation induced food hoarding in gonadectomized NMRI mouse model: focus on neural oxidative status

Environmental uncertainty, such as food deprivation, may alter internal milieu of nervous system through various mechanisms. In combination with circumstances of stress or aging, high consumption of unsaturate...

Authors: Noushin Nikray, Isaac Karimi, Zahraminoosh Siavashhaghighi, Lora A. Becker and Mohammad Mehdi Mofatteh

Anti-inflammatory effects of minocycline are mediated by retinoid signaling

Minocycline is a lipophilic tetracycline of increasing appeal in neuroscience as it inhibits microglial activation, a mechanism involved in numerous neuropsychiatric disorders. Own data point towards retinoid-...

Authors: Vera Clemens, Francesca Regen, Nathalie Le Bret, Isabella Heuser and Julian Hellmann-Regen

Transcranial focused ultrasound stimulation of motor cortical areas in freely-moving awake rats

Low-intensity transcranial focused ultrasound (tFUS) has emerged as a new non-invasive modality of brain stimulation with the potential for high spatial selectivity and penetration depth. Anesthesia is typical...

Authors: Wonhye Lee, Phillip Croce, Ryan W. Margolin, Amanda Cammalleri, Kyungho Yoon and Seung-Schik Yoo

Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study

Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capab...

Authors: Leo Ai, Priya Bansal, Jerel K. Mueller and Wynn Legon