Articles

Association between circle of Willis and ischemic stroke: a systematic review and meta-analysis

Circle of Willis is the main structure that provides constant and regular blood flow to the brain, protects the brain from ischemia. Stroke has remained the second leading cause of death globally in the last f...

Authors: Mohammed Oumer, Mekuriaw Alemayehu and Abebe Muche

Post-status epilepticus treatment with the Fyn inhibitor, saracatinib, improves cognitive function in mice

Status epilepticus (SE) is a life-threatening neurological disorder. The hippocampus, as an important area of the brain that regulates cognitive function, is usually damaged after SE, and cognitive deficits of...

Authors: Xin-Ming Luo, Jing Zhao, Wen-Yue Wu, Jie Fu, Zheng-Yu Li, Ming Zhang and Jie Lu

A dimension reduction technique applied to regression on high dimension, low sample size neurophysiological data sets

A common problem in neurophysiological signal processing is the extraction of meaningful information from high dimension, low sample size data (HDLSS). We present RoLDSIS (regression on low-dimension spanned i...

Authors: Adrielle C. Santana, Adriano V. Barbosa, Hani C. Yehia and Rafael Laboissière

29th Annual Computational Neuroscience Meeting: CNS*2020

Authors:

Distraction by a cognitive task has a higher impact on electrophysiological measures compared with conditioned pain modulation

Conditioned pain modulation (CPM) evaluates the effect of a painful conditioning stimulus (CS) on a painful test stimulus (TS). Using painful cutaneous electrical stimulation (PCES) as TS and painful cold wate...

Authors: A. T. L. Do, E. K. Enax-Krumova, Ö. Özgül, L. B. Eitner, S. Heba, M. Tegenthoff, C. Maier and O. Höffken

Target detection in healthy 4-week old piglets from a passive two-tone auditory oddball paradigm

Passive auditory oddball tests are effort independent assessments that evaluate auditory processing and are suitable for paediatric patient groups. Our goal was to develop a two-tone auditory oddball test pro...

Authors: R. Anna Oeur and Susan S. Margulies

Sex-dimorphic neuroestradiol regulation of ventromedial hypothalamic nucleus glucoregulatory transmitter and glycogen metabolism enzyme protein expression in the rat

Ventromedial hypothalamic nucleus (VMN) gluco-regulatory transmission is subject to sex-specific control by estradiol. The VMN is characterized by high levels of aromatase expression.

Authors: Md. Main Uddin, Mostafa M. H. Ibrahim and Karen P. Briski

Enriched environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice

Transcription factor 4 (TCF4) has been linked to human neurodevelopmental disorders such as intellectual disability, Pitt-Hopkins Syndrome (PTHS), autism, and schizophrenia. Recent work demonstrated that TCF4 par...

Authors: Katharina Braun, Benjamin M. Häberle, Marie-Theres Wittmann and D. Chichung Lie

Autistic traits are associated with the functional connectivity of between—but not within—attention systems in the general population

Previous studies have demonstrated that individuals with autism spectrum disorder (ASD) exhibit dysfunction in the three attention systems (i.e., alerting, orienting, and executive control) as well as atypical re...

Authors: Sayaka Yoshimura, Kei Kobayashi, Tsukasa Ueno, Takashi Miyagi, Naoya Oishi, Toshiya Murai and Hironobu Fujiwara

Occipital repetitive transcranial magnetic stimulation does not affect multifocal visual evoked potentials

To identify mechanisms of cortical plasticity of the visual cortex and to quantify their significance, sensitive parameters are warranted. In this context, multifocal visual evoked potentials (mfVEPs) can make...

Authors: Robert Kolbe, Aykut Aytulun, Ann-Kristin Müller, Marius Ringelstein, Orhan Aktas, Alfons Schnitzler, Hans-Peter Hartung, Stefan Jun Groiss and Philipp Albrecht

Emotion regulation through bifocal processing of fear inducing and disgust inducing stimuli

We present first-time evidence for the immediate neural and behavioral effects of bifocal emotional processing via visualized tapping for two different types of negative emotions (fear and disgust) in a sample...

Authors: Dina Wittfoth, Antonia Pfeiffer, Michael Bohne, Heinrich Lanfermann and Matthias Wittfoth

Crossed cerebellar diaschisis after stroke detected noninvasively by arterial spin-labeling MR imaging

As a noninvasive perfusion-weighted MRI technique, arterial spin-labeling (ASL) was becoming increasingly used to evaluate cerebral hemodynamics in many studies. The relation between ASL-MRI and crossed cerebe...

Authors: Juan Wang, Li-Jun Pan, Bin Zhou, Jin-Yan Zu, Yi-Xu Zhao, Yang Li, Wan-Qiu Zhu, Lei Li, Jian-Rong Xu and Zeng-Ai Chen

Effect of acute noise trauma on the gene expression profile of the hippocampus

This study aimed to investigate the changes in the expression of hippocampal genes upon acute noise exposure.

Authors: Chang Ho Lee, Kyung Woon Kim, So Min Lee and So Young Kim

Correction to: Gender differences in nerve regeneration after sciatic nerve injury and repair in healthy and in type 2 diabetic Goto-Kakizaki rats

An amendment to this paper has been published and can be accessed via the original article.

Authors: Lena Stenberg and Lars B. Dahlin

Neurologic effects of short-term treatment with a soluble epoxide hydrolase inhibitor after cardiac arrest in pediatric swine

Cardiac arrest (CA) is the most common cause of acute neurologic insult in children. Many survivors have significant neurocognitive deficits at 1 year of recovery. Epoxyeicosatrienoic acids (EETs) are multifun...

Authors: Caitlin E. O’Brien, Polan T. Santos, Ewa Kulikowicz, Jennifer K. Lee, Raymond C. Koehler and Lee J. Martin

Does conserved domain SOD1 mutation has any role in ALS severity and therapeutic outcome?

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative fatal disease that can affect the neurons of brain and spinal cord. ALS genetics has identified various genes to be associated with diseas...

Authors: Surinder Pal, Abha Tiwari, Kaushal Sharma and Suresh Kumar Sharma

Sensory gating and suppression of subjective peripheral sensations during voluntary muscle contraction

During voluntary muscle contraction, sensory information induced by electrostimulation of the nerves supplying the contracting muscle is inhibited and the somatosensory evoked potentials (SEPs) amplitude decre...

Authors: Terumasa Takahara, Hidetaka Yamaguchi, Kazutoshi Seki and Sho Onodera

Autoreceptor control of serotonin dynamics

Serotonin is a neurotransmitter that has been linked to a wide variety of behaviors including feeding and body-weight regulation, social hierarchies, aggression and suicidality, obsessive compulsive disorder, ...

Authors: Janet Best, William Duncan, Farrah Sadre-Marandi, Parastoo Hashemi, H. Frederik Nijhout and Michael Reed

Aberrant functional connectivity in resting state networks of ADHD patients revealed by independent component analysis

ADHD is one of the most common psychiatric disorders in children and adolescents. Altered functional connectivity has been associated with ADHD symptoms. This study aimed to investigate abnormal changes in the...

Authors: Huayu Zhang, Yue Zhao, Weifang Cao, Dong Cui, Qing Jiao, Weizhao Lu, Hongyu Li and Jianfeng Qiu

NGF receptors and PI3K/AKT pathway involved in glucose fluctuation-induced damage to neurons and α-lipoic acid treatment

Glucose fluctuation promotes neuronal apoptosis, which plays a central role in diabetic encephalopathy (DE). Nerve growth factor (NGF), and its interaction with high-affinity (TrkA) and low-affinity (p75NTR) r...

Authors: Ting Yan, Zhihui Zhang and Danqing Li

Distributed causality in resting-state network connectivity in the acute and remitting phases of RRMS

Although previous studies have shown that intra-network abnormalities in brain functional networks are correlated with clinical/cognitive impairment in multiple sclerosis (MS), there is little information rega...

Authors: Lin Wu, Muhua Huang, Fuqing Zhou, Xianjun Zeng and Honghan Gong

Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants

Frontotemporal dementia (FTD) is the second leading cause of early onset dementia following Alzheimer’s disease. It involves atrophy of the frontal and temporal regions of the brain affecting language, memory,...

Authors: Lalitha Venkataraman, Ping He, Galam Khan, Brent T. Harris and Michael R. Sierks

Inter-scanner reproducibility of brain volumetry: influence of automated brain segmentation software

The inter-scanner reproducibility of brain volumetry is important in multi-site neuroimaging studies, where the reliability of automated brain segmentation (ABS) tools plays an important role. This study aimed...

Authors: Sirui Liu, Bo Hou, Yiwei Zhang, Tianye Lin, Xiaoyuan Fan, Hui You and Feng Feng

Median nerve conduction studies in rabbits

When planning nerve conduction studies using animal models, the sciatic nerve is often used and the upper extremity nerves are not preferred due to the size of laboratory animals. This study aimed to present t...

Authors: Basak Mansiz-Kaplan, Secil Pervane-Vural, Koray Gursoy and Baris Nacir

MicroRNA-138 promotes neuroblastoma SH-SY5Y cell apoptosis by directly targeting DEK in Alzheimer’s disease cell model

Alzheimer’s disease (AD) is a progressive neuro-degenerative disease with a major manifestation of dementia. MicroRNAs were reported to regulate the transcript expression in patients with Alzheimer’s disease (...

Authors: Jin Miao, Jin Jing, Yixiang Shao and Huaichang Sun

Opposing effects of antibiotics and germ-free status on neuropeptide systems involved in social behaviour and pain regulation

Recent research has revealed that the community of microorganisms inhabiting the gut affects brain development, function and behaviour. In particular, disruption of the gut microbiome during critical developme...

Authors: Katerina V. A. Johnson and Philip W. J. Burnet

Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson’s disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity

Parkinson’s disease (PD) is a disease of the central nervous system that progressively affects the motor system. Epidemiological studies have provided evidence that exposure to agriculture-related occupations ...

Authors: Rodney C. P. Go, Michael J. Corley, G. Webster Ross, Helen Petrovitch, Kamal H. Masaki, Alika K. Maunakea, Qimei He and Maarit I. Tiirikainen

Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study

One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phen...

Authors: Ron Nudel, Camilla A. J. Christiani, Jessica Ohland, Md Jamal Uddin, Nicoline Hemager, Ditte Ellersgaard, Katrine S. Spang, Birgitte K. Burton, Aja N. Greve, Ditte L. Gantriis, Jonas Bybjerg-Grauholm, Jens Richardt M. Jepsen, Anne A. E. Thorup, Ole Mors, Thomas Werge and Merete Nordentoft

Neuroprotective effects of magnesium l-threonate in a hypoxic zebrafish model

Hypoxia inhibits the uptake of glutamate (a major neurotransmitter in the brain closely related to cognitive function) into brain cells, and the initial response of cells to cortical hypoxia depends on glutama...

Authors: Young-Sung Kim, Young Ju Won, Byung Gun Lim, Too Jae Min, Yeon-Hwa Kim and Il Ok Lee

NeuroConstruct-based implementation of structured-light stimulated retinal circuitry

Retinal circuitry provides a fundamental window to neural networks, featuring widely investigated visual phenomena ranging from direction selectivity to fast detection of approaching motion. As the divide betw...

Authors: Miriam Elbaz, Rachel Buterman and Elishai Ezra Tsur

Hcfc1a regulates neural precursor proliferation and asxl1 expression in the developing brain

Precise regulation of neural precursor cell (NPC) proliferation and differentiation is essential to ensure proper brain development and function. The HCFC1 gene encodes a transcriptional co-factor that regulates ...

Authors: Victoria L. Castro, Joel F. Reyes, Nayeli G. Reyes-Nava, David Paz and Anita M. Quintana

Anodal transcranial direct current stimulation reduces motor slowing in athletes and non-athletes

Motor fatigability describes a phenomenon that occurs when exhaustive exercise or physically demanding tasks are executed over an extended period of time. Concerning fast repetitive movements, it is noticeable...

Authors: Oliver Seidel-Marzi and Patrick Ragert

Repeated social defeat promotes persistent inflammatory changes in splenic myeloid cells; decreased expression of β-arrestin-2 (ARRB2) and increased expression of interleukin-6 (IL-6)

Previous studies suggest that persistent exposure to social stress in mammals may be associated with multiple physiological effects. Here, we examine the effects of social stress in rats, i.e. repeated social ...

Authors: Dhaksshaginy Rajalingam, Ingeborg Nymoen, Daniel Pitz Jacobsen, Mina Baarnes Eriksen, Erik Dissen, Morten Birkeland Nielsen, Ståle Valvatne Einarsen and Johannes Gjerstad

Dl-3-n-Butylphthalide promotes neovascularization and neurological recovery in a rat model of intracerebral hemorrhage

Cerebral stroke occurs following ischemic and hemorrhagic lesions in the brain. Survival and recovery of stroke patients depend on the severity of the initial injury but also the therapeutic approaches applied...

Authors: Ewen Tu, Qiong Chen, Li Tan and Yan Wang

Alexithymia and automatic processing of facial emotions: behavioral and neural findings

Alexithymia is a personality trait characterized by difficulties identifying and describing feelings, an externally oriented style of thinking, and a reduced inclination to imagination. Previous research has s...

Authors: Nicole Rosenberg, Klas Ihme, Vladimir Lichev, Julia Sacher, Michael Rufer, Hans Jörgen Grabe, Harald Kugel, André Pampel, Jöran Lepsien, Anette Kersting, Arno Villringer and Thomas Suslow

Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock

Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from oxidative stress. Stabilization of PNPH with bound ...

Authors: Soichiro Seno, Jun Wang, Suyi Cao, Manda Saraswati, Sharon Park, Jan Simoni, Li Ma, Bohdan Soltys, Carleton J. C. Hsia, Raymond C. Koehler and Courtney L. Robertson

Cathodal tDCS exerts neuroprotective effect in rat brain after acute ischemic stroke

Transcranial direct current stimulation (tDCS) is a non-invasive brain modulation technique that has been proved to exert beneficial effects in the acute phase of stroke. To explore the underlying mechanism, w...

Authors: Ke-Ying Zhang, Gang Rui, Jun-Ping Zhang, Ling Guo, Guang-Zhou An, Jia-Jin Lin, Wei He and Gui-Rong Ding

The impact of mental fatigue on brain activity: a comparative study both in resting state and task state using EEG

Mental fatigue is usually caused by long-term cognitive activities, mainly manifested as drowsiness, difficulty in concentrating, decreased alertness, disordered thinking, slow reaction, lethargy, reduced work...

Authors: Gang Li, Shan Huang, Wanxiu Xu, Weidong Jiao, Yonghua Jiang, Zhao Gao and Jianhua Zhang

Conformity-like behaviour in mice observing the freezing of other mice: a model of empathy

Empathy refers to the ability to recognise and share emotions with others. Several research groups have recognised observational fear in mice as a useful behavioural model for assessing their ability to empath...

Authors: Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto and Takeshi Ishihara

COX5A over-expression protects cortical neurons from hypoxic ischemic injury in neonatal rats associated with TPI up-regulation

Neonatal hypoxic-ischemic encephalopathy (HIE) represents as a major cause of neonatal morbidity and mortality. However, the underlying molecular mechanisms in brain damage are still not fully elucidated. This...

Authors: Ya Jiang, Xue Bai, Ting-Ting Li, Mohammed AL-Hawwas, Yuan Jin, Yu Zou, Yue Hu, Lin-Yi Liu, Ying Zhang, Qing Liu, Hao Yang, Jun Ma, Ting-Hua Wang, Jia Liu and Liu-Lin Xiong

Correction to: The role of C-afferents in mediating neurogenic vasodilatation in plantar skin after acute sciatic nerve injury in rats

An amendment to this paper has been published and can be accessed via the original article.

Authors: Tao Zhang, Jiahui Niu, Yaxian Wang, Junying Yan, Wen Hu and Daguo Mi

Noise exposure alters MMP9 and brevican expression in the rat primary auditory cortex

This study aimed to investigate the changes in molecules related to perineuronal nets (PNNs) and synaptic transporters in the primary auditory cortices of rats with noise-induced hearing loss. Female Sprague–D...

Authors: Sung-su Park, Da-hye Lee, So Min Lee, Chang Ho Lee and So Young Kim

The role of C-afferents in mediating neurogenic vasodilatation in plantar skin after acute sciatic nerve injury in rats

Vasomotor regulation of dermal blood vessels, which are critical in the function of the skin in thermoregulatory control, involves both neural and non-neural mechanisms. Whereas the role of sympathetic nerves ...

Authors: Tao Zhang, Jiahui Niu, Yaxian Wang, Junying Yan, Wen Hu and Daguo Mi

When gratitude and cooperation between friends affect inter-brain connectivity for EEG

Recently several studies in the psychological and social field have investigated the social function of gift exchange as a useful way for the consolidation of interpersonal and social relationships and the imp...

Authors: Michela Balconi, Giulia Fronda and Maria Elide Vanutelli

Intravenous methylprednisolone or immunoglobulin for anti-glutamic acid decarboxylase 65 antibody autoimmune encephalitis: which is better?

Patients positive for anti-glutamic acid decarboxylase 65 (GAD65) antibodies have attracted increasing attention. Their clinical manifestations are highly heterogeneous and can be comorbid with tumors. Current...

Authors: Tao-Ran Li, Yu-Di Zhang, Qun Wang, Xiao-Qiu Shao, Zhi-Mei Li and Rui-Juan Lv

Dopamine response gene pathways in dorsal striatum MSNs from a gene expression viewpoint: cAMP-mediated gene networks

Medium spiny neurons (MSNs) comprise the main body (95% in mouse) of the dorsal striatum neurons and represent dopaminoceptive GABAergic neurons. The cAMP (cyclic Adenosine MonoPhosphate)—mediated cascade of e...

Authors: Vladimir N. Babenko, Anna G. Galyamina, Igor B. Rogozin, Dmitry A. Smagin and Natalia N. Kudryavtseva

Neuropathological changes in dorsal root ganglia induced by pyridoxine in dogs

Pyridoxine (PDX; vitamin B₆), is an essential vitamin. PDX deficiency induces various symptoms, and when PDX is misused it acts as a neurotoxicant, inducing severe sensory neuropathy.

Authors: Sumin Yun, Woosuk Kim, Min Soo Kang, Tae Hyeong Kim, Yoonhwan Kim, Jin-Ok Ahn, Jung Hoon Choi, In Koo Hwang and Jin-Young Chung

Correction to: Wnt3a induces exosome secretion from primary cultured rat microglia

Following the publication of this article [1], it has been noted by the authors that an image of the same cell nuclei has been used in error twice, in Fig. 8, parts A and B. These images are redundant in this ...

Authors: Claudie Hooper, Ricardo Sainz-Fuertes, Steven Lynham, Abdul Hye, Richard Killick, Alice Warley, Cecilia Bolondi, Jennifer Pocock and Simon Lovestone

Neuromyelitis optica: a pilot study of clinical presentation and status of serological biomarker AQP4 among patients admitted to a tertiary centre in NCNS, Sudan

Neuromyelitis optica (NMO) is a demyelinating disease primarily affecting the optic nerves and spinal cord. It is distinguished from other demyelinating conditions by the presence of AQP4-IgG and serum aquapor...

Authors: Etedal Ahmed AbuElbasher Ibrahim, Fatima Gammer and Alsadig Gassoum

Suppression of behavioral activity and hippocampal noradrenaline caused by surgical stress in type 2 diabetes model mice

There has been much discussion recently about the occurrence of neuropsychological complications during the perioperative period. Diabetes is known to be one of the metabolic risk factors. Although the number ...

Authors: Momoka Nishimura, Yuki Nomura, Moritoki Egi, Norihiko Obata, Makoto Tsunoda and Satoshi Mizobuchi