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Figure 7 | BMC Neuroscience

Figure 7

From: Transplantation of human neural stem cells transduced with Olig2 transcription factor improves locomotor recovery and enhances myelination in the white matter of rat spinal cord following contusive injury

Figure 7

Transplantation of F3.Olig2 NSCs improves locomotor recovery. (A) Comparison of BBB locomotor scale. An arrow indicates the time point when transplantation was performed. N = 11, 12, and 12 for Vehicle (Veh), F3, and F3.Olig2 groups, respectively. Error bars represent mean ± SD. * = p < 0.05, ** = p < 0.01 by repeated measures two-way ANOVA followed by posthoc Tukey's analysis. (B) Grid walk. The number of hindpaw placement errors on grid per run was counted at 4 and 7 weeks (4w and 7w, respectively) after transplantation. N = 9, 8, and 9 for Vehicle, F3, and F3.Olig2 groups, respectively. Error bars represent mean ± SD. (C-E) Foot print analysis. (C) Interlimb distance (ILD) or base of support. (D) Stride length (SL) of the left hindlimb. (E) SL of the right hindlimb. N = 5, 4, 5, and 5 for sham, Vehicle, F3, F3.Olig2 groups, respectively. Error bars represent mean ± SD. * = p < 0.05 compared to sham. For B - E, stippled, white, gray, and black bars represent sham, Vehicle, F3, and F3.Olig2 groups, respectively.

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BMC Neuroscience

ISSN: 1471-2202

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