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  1. In the cerebral cortex, disinhibited activity is characterized by propagating waves that spread across neural tissue. In this pathological state, a widely reported form of activity are spiral waves that travel...

    Authors: Megan Boucher-Routhier and Jean-Philippe Thivierge
    Citation: BMC Neuroscience 2023 24:22
  2. Duchenne muscular dystrophy is a X-linked disease characterized by severe and progressive muscle weakness, alongside cognitive impairment and a range of neurobehavioral disorders secondary to brain dystrophin ...

    Authors: Abbe H. Crawford, Natasha L. Hornby, Alerie G. de la Fuente and Richard J. Piercy
    Citation: BMC Neuroscience 2023 24:21
  3. Vinpocetine (Vin) is known as a phosphodiesterase 1 inhibitor (PDE1-I) drug with multilateral effects, including antioxidant and anti-inflammatory activity. In this research, we investigated the neuroprotectiv...

    Authors: Meysam Shekarian, Iraj Salehi, Safoura Raoufi, Masoumeh Asadbegi, Masoumeh Kourosh-Arami and Alireza Komaki
    Citation: BMC Neuroscience 2023 24:20
  4. Sexual differences in the biology of human stem cells are increasingly recognized to influence their proliferation, differentiation and maturation. Especially in neurodegenerative diseases such as Alzheimers d...

    Authors: Tarek Niemann, Johannes F.W. Greiner, Christian Kaltschmidt and Barbara Kaltschmidt
    Citation: BMC Neuroscience 2023 24:19
  5. Although ataxia is associated with cerebellar dysfunction, little is known about the effects of 3-AP exposure on Purkinje cell electrophysiological properties. Here, we evaluated these parameters in cerebellar...

    Authors: Hoda Ranjbar, Monavareh Soti, Kristi A. Kohlmeier, Mahyar Janahmadi and Mohammad Shabani
    Citation: BMC Neuroscience 2023 24:18
  6. Microglial polarization and the subsequent neuroinflammatory response and oxidative stress are contributing factors for traumatic brain injury (TBI) plus hemorrhagic shock (HS) induced brain injury. In the pre...

    Authors: Jimin Cai, Yang Yang, Jiahui Han, Yu Gao, Xin Li and Xin Ge
    Citation: BMC Neuroscience 2023 24:17
  7. Life-long early ART (started before age 2 years), often with periods of treatment interruption, is now the standard of care in pediatric HIV infection. Although cross-sectional studies have investigated HIV-re...

    Authors: Emmanuel C. Nwosu, Martha J. Holmes, Mark F. Cotton, Els Dobbels, Francesca Little, Barbara Laughton, Andre van der Kouwe, Frances Robertson and Ernesta M. Meintjes
    Citation: BMC Neuroscience 2023 24:15
  8. Neuroinflammation plays a critical role in Amyloid-β (Aβ) pathophysiology. The cytokine, interleukin-17A (IL-17) is involved in the learning and memory process in the central nervous system and its level was r...

    Authors: Yulan Liu, Yang Meng, Chenliang Zhou, Juanjuan Yan, Cuiping Guo and Weiguo Dong
    Citation: BMC Neuroscience 2023 24:14
  9. During non-rapid eye movement sleep (NREM), alternating periods of synchronised high (ON period) and low (OFF period) neuronal activity are associated with high amplitude delta band (0.5–4 Hz) oscillations in ...

    Authors: Christian D. Harding, Mathilde C. C. Guillaumin, Lukas B. Krone, Martin C. Kahn, Cristina Blanco-Duque, Christian Mikutta and Vladyslav V. Vyazovskiy
    Citation: BMC Neuroscience 2023 24:13
  10. Trait anxiety refers to a stable tendency to experience fears and worries across many situations. High trait anxiety is a vulnerability factor for the development of psychopathologies. Self-reported trait anxi...

    Authors: Vivien Günther, Jonas Pecher, Carolin Webelhorst, Charlott Maria Bodenschatz, Simone Mucha, Anette Kersting, Karl-Titus Hoffmann, Boris Egloff, Donald Lobsien and Thomas Suslow
    Citation: BMC Neuroscience 2023 24:12
  11. Authors: Melanni Nanni-Zepeda, Sarah Alizadeh, Tara Chand, Vanessa Kasties, Yan Fan, Johan van der Meer, Luisa Herrmann, Johannes C. Vester, Myron Schulz, Britta Naschold and Martin Walter
    Citation: BMC Neuroscience 2023 24:11

    The original article was published in BMC Neuroscience 2022 23:68

  12. Glioblastoma (GBM) is the most common malignant intracranial tumor with a low survival rate. However, only few drugs responsible for GBM therpies, hence new drug development for it is highly required. The natu...

    Authors: Jinlin Pan, Rongchuan Zhao, Caihua Dong, Jiao Yang, Ruobing Zhang, Minxuan Sun, Nafees Ahmad, Yuanshuai Zhou and Yanxiang Liu
    Citation: BMC Neuroscience 2023 24:10
  13. As a common complication in elderly patients after surgery/anesthesia, postoperative cognitive dysfunction (POCD) is mainly characterized by memory, attention, motor, and intellectual retardation. Neuroinflamm...

    Authors: Junjie Zhou, Chao Zhang, Xu Fang, Naixin Zhang, Xiaoxi Zhang and Zhaoqiong Zhu
    Citation: BMC Neuroscience 2023 24:9
  14. Circular RNAs (circRNAs) can act as microRNA (miRNA) sponges, thus regulating gene expression. The role of circRNAs in the process of oxygen-glucose deprivation/reoxygenation (OGD/R) is unclear. Here, we explo...

    Authors: Lei Yang, Hong Du, Xuejing Zhang, Bulang Gao, Dongliang Zhang, Zongrong Qiao, Xianhui Su, Tong Bao and Siqin Han
    Citation: BMC Neuroscience 2023 24:8
  15. Ischemic stroke is a major cause of death and disability worldwide. Translation into the clinical setting of neuroprotective agents showing promising results in pre-clinical studies has systematically failed. ...

    Authors: Laura Ramiro, Júlia Faura, Alba Simats, Paula García-Rodríguez, Feifei Ma, Luna Martín, Francesc Canals, Anna Rosell and Joan Montaner
    Citation: BMC Neuroscience 2023 24:7
  16. Multispectral fluorescence imaging coupled with linear unmixing is a form of image data collection and analysis that allows for measuring multiple molecular signals in a single biological sample. Multiple fluo...

    Authors: Vijay Sadashivaiah, Madhavi Tippani, Stephanie C. Page, Sang Ho Kwon, Svitlana V. Bach, Rahul A. Bharadwaj, Thomas M. Hyde, Joel E. Kleinman, Andrew E. Jaffe and Kristen R. Maynard
    Citation: BMC Neuroscience 2023 24:6
  17. Autism spectrum condition or ‘autism’ is associated with numerous genetic risk factors including the polygenic 16p11.2 microdeletion. The balance between excitatory and inhibitory neurons in the cerebral cortex i...

    Authors: Yifei Yang, Sam A. Booker, James M. Clegg, Idoia Quintana-Urzainqui, Anna Sumera, Zrinko Kozic, Owen Dando, Sandra Martin Lorenzo, Yann Herault, Peter C. Kind, David J. Price and Thomas Pratt
    Citation: BMC Neuroscience 2023 24:5
  18. A historically definitive marker for cholinergic neurons is choline acetyltransferase (ChAT), a synthesizing enzyme for acetylcholine, (ACh), which can be found in high concentrations in cholinergic neurons, b...

    Authors: Rashmi Gamage, Laszlo Zaborszky, Gerald Münch and Erika Gyengesi
    Citation: BMC Neuroscience 2023 24:4
  19. The release of various neurotransmitters and thereby the excitability of neuronal circuits are regulated by the endocannabinoid system in an activity-dependent manner. Hippocampal long-term potentiation (LTP) ...

    Authors: Masoumeh Nazari, Seyed Asaad Karimi, Somayeh Komaki, Masoumeh Kourosh Arami and Alireza Komaki
    Citation: BMC Neuroscience 2023 24:3
  20. The head-twitch response (HTR) in mice is considered a behavioral model for hallucinogens and serotonin 5-HT2A receptor function, as well as Tourette syndrome in humans. It is mediated by 5-HT2A receptor agonists...

    Authors: Yina Sun, Seetha Chebolu, Stone Skegrud, Setareh Kamali and Nissar A. Darmani
    Citation: BMC Neuroscience 2023 24:2
  21. Cataplexy is a loss of muscle tone that can lead to postural collapse, disturbing the daily life of narcolepsy patients; it is often triggered by positive emotions such as laughter in human patients. Narcoleps...

    Authors: Mayuko Yoshida, Koki Yamamoto and Tomoyuki Kuwaki
    Citation: BMC Neuroscience 2022 23:82
  22. Hearing loss is a major health problem and psychological burden in humans. Mouse models offer a possibility to elucidate genes involved in the underlying developmental and pathophysiological mechanisms of hear...

    Authors: Dominik Thalmeier, Gregor Miller, Elida Schneltzer, Anja Hurt, Martin Hrabě deAngelis, Lore Becker, Christian L. Müller and Holger Maier
    Citation: BMC Neuroscience 2022 23:81
  23. In the treatment of ischemic cerebral stroke (ICS), most conventional treatments, including carotid endarterectomy and carotid artery stenting, may cause cerebral ischemia-reperfusion injury (CIRI). For treate...

    Authors: Lu Yin, Tengfei Yu, Linggang Cheng, Xinyao Liu, Wei Zhang, Hongxia Zhang, Lijuan Du and Wen He
    Citation: BMC Neuroscience 2022 23:80
  24. Infant emotional stimuli can preferentially engage adults’ attention and provide valuable information essential for successful interaction between adults and infants. Exploring the neural processes of recogniz...

    Authors: Kaihua Zhang, Xiaoyu Du, Xianling Liu, Wei Su, Zhenhua Sun, Mengxing Wang and Xiaoxia Du
    Citation: BMC Neuroscience 2022 23:79
  25. Electromagnetic induction has recently been considered as an important factor affecting the activity of neurons. However, as an important form of intervention in epilepsy treatment, few people have linked the ...

    Authors: Yuqin Sun, Yuting Chen, Hudong Zhang and Yuan Chai
    Citation: BMC Neuroscience 2022 23:78
  26. Succinic semialdehyde dehydrogenase deficiency (SSADH-D) is an autosomal recessive gamma-aminobutyric acid (GABA) metabolism disorder that can arise due to ALDH5A1 mutations, resulting in severe, progressive, unt...

    Authors: Xiaodan Chen, Minzhi Peng, Yanna Cai, Chengcheng Zhou and Li Liu
    Citation: BMC Neuroscience 2022 23:77
  27. Intraluminal monofilament model of middle cerebral artery occlusion (MCAO) is widely adopted for ischemic stroke; and Sprague–Dawley (SD) rats are commonly used rodents for preclinical research. Due to the pau...

    Authors: I. J. Biose, W. H. Chastain, H. Wang, B. Ouvrier and G. J. Bix
    Citation: BMC Neuroscience 2022 23:75
  28. Sodium formononetin-3ʹ-sulphonate (Sul-F) may alleviate I/R injury in vivo with uncertain mechanism. Endoplasmic reticulum (ER) stress-mediated apoptosis participates in the process of cerebral ischemia‐reperf...

    Authors: Yue Bai, Zhiwei He, Weisong Duan, He Gu, Kefeng Wu, Wei Yuan, Wenkang Liu, Huaipeng Huang and Yanan Li
    Citation: BMC Neuroscience 2022 23:74
  29. In the military, constant physiological and psychological stress encountered by Soldiers can lead to development of the combat and operational stress reaction (COSR), which can effect pain management. Similar ...

    Authors: Misty M. Strain, Sirima Tongkhuya, Nathan Wienandt, Farah Alsadoon, Roger Chavez, Jamar Daniels, Thomas Garza, Alex V. Trevino, Kenney Wells, Thomas Stark, John Clifford and Natasha M. Sosanya
    Citation: BMC Neuroscience 2022 23:73
  30. To explore the feasibility of diffusion-weighted imaging (DWI) metrics to predict the histologic subtypes and genetic status of gliomas (e.g., IDH, MGMT, and TERT) noninvasively.

    Authors: Sirui Liu, Yiwei Zhang, Ziren Kong, Chendan Jiang, Yu Wang, Dachun Zhao, Hui You, Wenbin Ma and Feng Feng
    Citation: BMC Neuroscience 2022 23:72
  31. Calcium imaging is a powerful technique for recording cellular activity across large populations of neurons. However, analysis methods capable of single-cell resolution in cultured neurons, especially for cult...

    Authors: Madhavi Tippani, Elizabeth A. Pattie, Brittany A. Davis, Claudia V. Nguyen, Yanhong Wang, Srinidhi Rao Sripathy, Brady J. Maher, Keri Martinowich, Andrew E. Jaffe and Stephanie Cerceo Page
    Citation: BMC Neuroscience 2022 23:71
  32. Obstructive sleep apnea (OSA) is mainly characterized by sleep fragmentation and chronic intermittent hypoxia (CIH), the latter one being associated with multiple organ injury. Recently, OSA-induced cognition ...

    Authors: Ningning She, Yewen Shi, Yani Feng, Lina Ma, Yuqi Yuan, Yitong Zhang, Zine Cao, Xi Chen, Bingjie Zhao, Haiqin Liu and Xiaoyong Ren
    Citation: BMC Neuroscience 2022 23:70
  33. Arginine-Vasopressin (AVP) is a nonapeptide that exerts multiple functions within the central nervous system and in the blood circulation that might contribute to outcome in critically ill patients. Sex differ...

    Authors: A. H. Podtschaske, J. Martin, B. Ulm, B. Jungwirth and S. M. Kagerbauer
    Citation: BMC Neuroscience 2022 23:69
  34. The multicomponent drug Neurexan (Nx4) was shown to reduce the neural stress network activation. We now investigated its effects on stress-induced resting state functional connectivity (RSFC) in dependence of ...

    Authors: Melanni Nanni-Zepeda, Sarah Alizadeh, Tara Chand, Vanessa Kasties, Yan Fan, Johan van der Meer, Luisa Herrmann, Johannes C. Vester, Myron Schulz, Britta Naschold and Martin Walter
    Citation: BMC Neuroscience 2022 23:68

    The Correction to this article has been published in BMC Neuroscience 2023 24:11

  35. Esketamine upregulates Zn2+-dependent matrix metalloproteinase 9 (MMP9) and increases the neuronal apoptosis in retinal ganglion cell layer during the early development. We aimed to test whether albumin can allev...

    Authors: Kan Zhang, Ruijing Ma, Luping Feng, Peiwen Liu, Shuang Cai, Chaoyang Tong and Jijian Zheng
    Citation: BMC Neuroscience 2022 23:66
  36. One of the most serious nervous system diseases is spinal cord injury(SCI), which is increasing for various reasons. Although no definitive treatment has yet been identified for SCI, one possible treatment is ...

    Authors: Arvin Naeimi, Arash Zaminy, Naser Amini, Raziye Balabandi and Zoleikha Golipoor
    Citation: BMC Neuroscience 2022 23:65
  37. The pathogenesis of neuropathic pain (NP) has not been fully elucidated. Gene changes in dorsal root ganglia (DRG) may contribute to the development of NP. Circular RNAs (circRNAs) are a class of endogenous no...

    Authors: Wanxia Xiong, Min Wei, Li Zhang, Jie Wang, Fan Liu and Zhiyao Wang
    Citation: BMC Neuroscience 2022 23:64
  38. Retinal ganglion cells (RGCs) are important retinal neurons that connect visual receptors to the brain, and lysine-specific demethylase 1 (LSD1) is implicated in the development of RGCs. This study expounded t...

    Authors: Xiuling Yu, Tongtong Niu and Chi Liu
    Citation: BMC Neuroscience 2022 23:63
  39. Inflammation and glutamate (GLU) are widely thought to participate in the pathogenesis of depression, and current evidence suggests that the development of depression is associated with the activation of the k...

    Authors: Xingying Wu, Bowen Chen, Zhong Di, Shuo Jiang, Haipeng Xu, Mengting Shi, Rong Hu, Shaopeng Sun, Zhujin Song, Jiapeng Liu, Ruijie Ma and Qin Guo
    Citation: BMC Neuroscience 2022 23:62
  40. In brain, microvascular endothelial cells are exposed to various forces, including shear stress (SS). However, little is known about the effects of high shear stress (HSS) on human brain microvascular endothel...

    Authors: Zhe Li, Jia-Nan Li, Qiang Li, Chun Liu, Lin-Hua Zhou, Qi Zhang and Yi Xu
    Citation: BMC Neuroscience 2022 23:61
  41. Chondroitinase ABC (chABC) is an enzyme could improve regeneration and thereby improving functional recovery of spinal cord injury (SCI) in rodent models. Degradation of the active enzyme and diffusion away fr...

    Authors: Atousa Sharifi, Ali Zandieh, Zahra Behroozi, Michael R. Hamblin, Sara Mayahi, Mahmoud Yousefifard and Fatemeh Ramezani
    Citation: BMC Neuroscience 2022 23:60
  42. The hooded seal (Cystophora cristata) exhibits impressive diving skills and can tolerate extended durations of asphyxia, hypoxia and oxidative stress, without suffering from irreversible neuronal damage. Thus, wh...

    Authors: Gerrit A. Martens, Cornelia Geßner, Carina Osterhof, Thomas Hankeln and Thorsten Burmester
    Citation: BMC Neuroscience 2022 23:59
  43. Opioids are among the most effective and commonly prescribed analgesics for the treatment of acute pain after spinal cord injury (SCI). However, morphine administration in the early phase of SCI undermines loc...

    Authors: Mabel N. Terminel, Carla Bassil, Josephina Rau, Amanda Trevino, Cristina Ruiz, Robert Alaniz and Michelle A. Hook
    Citation: BMC Neuroscience 2022 23:58
  44. Auditory steady-state responses (ASSRs) are periodic evoked responses to constant periodic auditory stimuli, such as click trains, and are suggested to be associated with higher cognitive functions in humans. ...

    Authors: Tomoya Nakamura, Trong Ha Dinh, Makoto Asai, Hiroshi Nishimaru, Jumpei Matsumoto, Tsuyoshi Setogawa, Hiroyuki Ichijo, Sokichi Honda, Hiroshi Yamada, Takuma Mihara and Hisao Nishijo
    Citation: BMC Neuroscience 2022 23:57
  45. Dysregulation of long noncoding RNA (lncRNA) expression is related to aging and age-associated neurodegenerative diseases, and the lncRNA expression profile in the aging hippocampus is not well characterized. ...

    Authors: Li Qi, Xiao Li, Shi-min Liu, Dan-li Jiao, Dan Hu, Xin-yao Ju, Shu-yu Zhao, Shu-han Si, Li Hu, Guo-na Li, Bing-zhe Ma, Shuang Zhou and Chen Zhao
    Citation: BMC Neuroscience 2022 23:56
  46. Neuronal injury induced in young rats by cerebral ischemia reperfusion (CIR) is known to differ substantially from that in adult rats. In the present study, we investigated the specific differences in neuronal...

    Authors: Jie Wang, Zihao Xia, Peng Sheng, Mengmeng Shen, Lidong Ding, Dezhi Liu and Bing Chun Yan
    Citation: BMC Neuroscience 2022 23:55

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