Figure 1From: Role of ionotropic GABA, glutamate and glycine receptors in the tonic and reflex control of cardiac vagal outflow in the ratVerification that dual bilateral microinjections in the ventral medulla inhibits cardiac vagal outflow. A representative trace is provided in panel A showing that microinjection of muscimol (100 mM, 100 nl) into four regions of the medulla where bradycardia greater than 50 bpm was evoked by prior microinjection of L-glutamate (100 mM, 50 nl) increases resting heart rate (HR) and prevents baroreflex mediated bradycardia. Grouped data (n = 4) shows that microinjection of muscimol into these four sites evokes a large increase in HR (panel B) and dramatically reduces baroreflex sensitivity (BRS, panel C). * P < 0.05.Back to article page