Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration

Table 2 Gene expression changes reported previously

			Expression Level (% of Naïve Control)
	Gene Name	Gene ID	Nv1	Nv10	Nv100
mPFC	Activity-related cytoskeleton-associated protein	Arc	43.9 ± 14**	76.8 ± 12	51.8 ± 10**
	Cocaine and amphetamine regulated transcript	CART	725.2 ± 130**	191.9 ± 55	190.3 ± 86
	Early growth response 1	Erg1	59.6 ± 9.2*	74.7 ± 15	74.5 ± 5.3
	FBJ osteosarcoma oncogene	Fos	41.7 ± 12**	58.1 ± 11**	53.1 ± 6.8**
	Neuropeptide Y	Npy	158.4 ± 21^#	94.5 ± 9.5	91 ± 5.2
	Nuclear receptor subfamily 4, group A, member 1	Nr4a1	35.1 ± 11**	53.4 ± 12*	49.4 ± 7.7*
NAc	Activity-related cytoskeleton-associated protein	Arc	83.5 ± 22	73.7 ± 12	49.5 ± 6.4*
	FBJ osteosarcoma oncogene	Fos	53.9 ± 16**	60.3 ± 6.7**	51.7 ± 62**
	Nuclear receptor subfamily 4, group A, member 1	Nr4a1	65.7 ± 20	63.4 ± 11	48.1 ± 5.1*

Data is presented as mean ± standard error of the mean (SEM), ANOVA with Student-Newman-Keuls post hoc testing; * p < 0.05, ** p < 0.01, # p < 0.001. Data previously reported in [12].

ISSN: 1471-2202