Figure 7From: The effects of different doses of estradiol (E2) on cerebral ischemia in an in vitro model of oxygen and glucose deprivation and reperfusion and in a rat model of middle carotid artery occlusionThe infarct volume in rats exposed to ischemia–reperfusion injury by MCAO receiving different doses of E2. (A) The OVX group resulted in larger infarct volume compared to the control group. 6 μg/kg and 20 μg/kg E2 replacement significantly decreased the infarct volume. 50 μg/kg E2 replacement group resulted in larger infarct volume than the control group and 6 μg/kg or 20 μg/kg E2 replacement group. (**p < 0.01 v.s. the control group, #p < 0.05 v.s. the OVX group, *p < 0.05 v.s. the control group and 6 μg/kg or 20 μg/kg E2 replacement group). (B) Representative photographs showing infarct volume in the different groups after the MACO.Back to article page