Figure 4

Contribution of NMDA-receptors. A: Superimposed suprathreshold corticostriatal responses in a dSPN during control (red trace) and after adding 50 μM APV to the superfusion (black trace, +APV). B: Superimposed suprathreshold response to intrastriatal stimulation in a dSPN in control (red trace) and after adding APV to the superfusion (black trace). C: Histogram summarizing results in a sample of neurons: APV-sensitive fraction of corticostriatal response in dSPNs is 43% (***P < 0.001), while APV-sensitive fraction of intrastriatal response in dSPNs is 24% (*P < 0.05). D: Digital subtraction of APV-sensitive component from corticostriatal response shows a quick rise and a plateau potential that most likely contributes to the duration of the response in dSPNs. E: Digital subtraction of APV-sensitive component from intrastriatal response shows mainly the monosynaptic PSP previously reported by several authors. F: Superimposed suprathreshold corticostriatal responses in an iSPN in control (green trace, control) and after adding APV to the superfusion (black trace, +APV). G: Superimposed suprathreshold response to intrastriatal stimulation in an iSPN in control (green trace) and after adding APV to the superfusion (black trace). H: Histogram representing results from a sample of neurons: APV-sensitive fraction of corticostriatal response in iSPNs is 21% (**P < 0.01), while APV-sensitive fraction of response to intrastriatal stimulation was statistically non-significant in the present sample (P > 0.05). I: Digital subtraction of APV-sensitive component from corticostriatal response shows a smaller plateau potential than that found in dSPNs. J: Digital subtraction of APV-sensitive component from response to intrastriatal stimulation shows a PSP slower than that shown in dSPNs.