Figure 7

Apparent ADAMTS activity: Apparent activity in the dentate gyrus of mice after entorhinal cortex lesion as measured by the ratio of the optical density of the ADAMTS-derived EAMESE fragment and the sum of the densities of the brevican core protein isoforms (>145 kD + 145 kD). Mean level of apparent activity was calculated at two, seven and thirty days after lesion. At two days after lesion, ADAMTS activity declined, whereas at seven days a significant 47% increase in ADAMTS activity was observed compared to the contralateral ADAMTS activity. Levels on the lesioned side were not different from the non-lesioned dentate in tissue collected thirty days after lesion.