Figure 9

Quantification of fluorescent Wld^S axons in whole-mounted peripheral nerve stumps from triple heterozygote mice after transection and crush injury at different time points. Partially degenerated YFP positive Wld^S axons that could be identified 15 and 20 days either after transection or crush injury showed axonal constrictions or interruptions in their proximal site but not further distal indicating an anterograde gradient of degeneration. They were assigned to the group "fragmented with anterograde gradient". Few entirely preserved fluorescent Wld^S axons could be only seen 15 days after transection and crush injury. They were assigned to the group "intact". The chart presents means and standard deviations.