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Figure 2 | BMC Neuroscience

Figure 2

From: Cognitive dysfunction in NFI knock-out mice may result from altered vesicular trafficking of APP/DRD3 complex

Figure 2

Clustering network connecting neurofibromin primary gene mutation with downstream cellular factors. Enlargement of signaling network connecting neurofibromin (Nf-1) with the dopamine 3 receptor (D3DR HUMAN) created through the GeneGo networking software. Neurofibromin is indicated as a binding partner for both the kinesin heavy chain and amyliod beta precursor protein (APP). APP binds through integrins to filamin A, a cytoskeletal organizational protein which in turn can bind to and possibly transport the dopamine 3 receptor.

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BMC Neuroscience

ISSN: 1471-2202

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