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Figure 4 | BMC Neuroscience

Figure 4

From: Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir

Figure 4

HIV PIs do not affect Notch 1 expression or processing in CEC. Western analyses of the expression of total Notch 1 (dark bars) and the percentage of Notch 1 processing (NICD) (lighter bars) after 5 μM exposure to A) saquinavir (SQV), B) indinavir (INV), C) nelfinavir (NFV), and D) ritonavir (RTV) for various lengths of time (1, 24, 48 and 96 h). E) quantitative real-time PCR analyses of Notch 1 mRNA levels after exposure to saquinavir (S), indinavir (I), nelfinavir (N), or ritonavir (R) for 1 or 48 h. No statistically significant differences were calculated by one way ANOVA. Graphs reflect results from three or more separate experiments.

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BMC Neuroscience

ISSN: 1471-2202

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