Persistent changes in spinal cord gene expression after recovery from inflammatory hyperalgesia: A preliminary study on pain memory

Table 2 Ontologic classification of genes differentially expressed at 24h and 28d (B).

Category	Number of sequences	% of total	p-value
*Protein synthesis/ribosome*
ribosome	18	5.20%	6.10E-12
protein biosynthesis	19	5.50%	3.60E-10
ribonucleoprotein complex	25	7.30%	1.80E-08
eukaryotic 43S preinitiation complex	7	2.00%	1.60E-05
eukaryotic 48S initiation complex	6	1.70%	6.00E-05
*Protein folding*
posttranslational protein folding	4	1.20%	2.40E-03
chaperone cofactor dependent protein folding	4	1.20%	1.40E-03
response to unfolded protein	6	1.70%	2.70E-03
*Immune response*
immunoglobulin domain	16	4.70%	4.90E-05
A-macroglobulin receptor	3	0.90%	1.20E-02
*Regulatory pathway*
response to stress	34	9.90%	5.50E-03
signal transduction inhibitor	4	1.20%	6.90E-03
cation binding	44	12.80%	3.60E-03
calmodulin binding	6	1.70%	7.50E-03

Functional analysis of differentially expressed transcript employed DAVID tools (see Methods for detailed description). To calculate background, Affychip has been used. Some transcripts represent in more than one category. Cutoff value for category selection p < 0.05.

ISSN: 1471-2202