Figure 6From: Shox2 is required for the proper development of the facial motor nucleus and the establishment of the facial nerves Shox2 is required for the proper development of the facial motor nucleus. a Diagram of a sagittal section through the P0 brain highlights the regions represented in b–v. b X-gal stained sagittal sections through P0 brains show a decrease in staining levels in the facial motor nucleus (nVII) of Nestin-Cre; Shox2 lacZ/flox (B″) animals as compared to controls (B′). c–v ISH on P0 control (c, e, g, i, k, m, o, q, s, u) and Nestin-Cre; Shox2 flox/− (d, f, h, j, l, n, p, r, t, v) sagittal sections shows loss of Shox2 expression (compare c to d, dashed-circle), and decreases in Isl1 (compare e to f, dashed-circle), Phox2b (compare g to h, dashed-circle), Cntn2 (compare i to j, dashed-circle), Tubb3 (compare k to l, dashed-circle), Periph (compare m to n, dashed-circle), Slc18a3 (compare o to p, dashed-circle), Slit2 (compare q to r, dashed-circle), Shh (compare s to t, dashed-circle) and Ptch1 (compare u to v, dashed-circle) expression in the facial motor nucleus. nV trigeminal nucleus, RTN retrotrapezoid nucleus. Scale bar 250 μm.Back to article page