Fig. 2
From: The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice
Long-chain PUFAs and their metabolites in brain tissue of wt and fat-1 mice. a Fatty acid composition in brain tissue of wt and fat-1 mice were analysed using GC. The only significant difference in n-3 PUFAs in wt and fat-1 brain tissue was observed for EPA (EPA in wt cerebella 0 ± 0; EPA in fat-1 cerebella 34.6 ± 19.5; p = 0.003), which was detectable only in the fat-1 mice tested. AA and DHA levels in wt and fat-1 mice were wt: 2549 ± 203, 4769 ± 539; fat-1: 2418 ± 169, 4904 ± 398 respectively. b Lipid metabolite profiles in brain tissue of wt and fat-1 mice were analysed using LC MS/MS. Similarly, levels of EPA-derived total HEPEs were significantly higher in fat-1 animals. Levels of AA-derived HETEs and DHA-derived HDHAs levels were similar among wt and fat-1 animals