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Fig. 5 | BMC Neuroscience

Fig. 5

From: Important modifications by sugammadex, a modified γ-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cells

Fig. 5

Time course of repetitive cumulative activation of I K(DR) obtained with or without SGX treatment. In A, the peak amplitude of each I K(DR) was measured during repetitive depolarizations from −50 to +50 mV with a duration of 10 ms at a rate of 70 Hz. Filled and open circles were obtained in untreated and SGX-treated cells respectively. Inset indicates the voltage protocol used. In B, original I K(DR) traces (a and b) in response to rapid membrane depolarization from −50 to +50 mV were shown. Traces a and b correspond to the data points labeled a and b in A. Arrowhead in traces a and b indicate the zero current level. Notably, in addition to inhibition of I K(DR) amplitude, SGX treatment can slow the rate of excessive cumulative activation of I K(DR) in response to repetitive stimuli. *Significantly different from the data from untreated cells (P < 0.05). Mean ± SEM (n = 9–10)

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BMC Neuroscience

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