Effects of escitalopram and paroxetine on mTORC1 signaling in the rat hippocampus under chronic restraint stress

BMC Neuroscience

Table 1 Summary of the two-way analysis of variance on changes in phosphorylated mTORC1, downstream effectors of mTORC1, and upstream activators of mTORC1 related to treatment, stress and on the interaction of treatment and stress

	Escitalopram		Paroxetine
	F	P	F	P
mTORC1
Drug	7.498	0.013	8.198	0.010
Stress	8.402	0.009	10.616	0.004
Drug × stress	10.662	0.004	6.990	0.016
Downstream effectors of mTORC1
4E-BP-1
Drug	13.592	0.001	12.403	0.002
Stress	20.717	<0.001	28.600	<0.001
Drug × stress	9.579	0.006	11.679	0.003
p70S6 K
Drug	8.868	0.007	5.866	0.025
Stress	17.816	<0.001	17.947	<0.001
Drug × stress	10.815	0.004	7.900	0.011
eIF4B
Drug	8.157	0.010	6.669	0.018
Stress	19.425	<0.001	16.753	0.001
Drug × stress	5.919	0.024	8.980	0.007
S6
Drug	4.194	0.050	6.878	0.016
Stress	12.204	0.002	12.117	0.002
Drug × stress	7.238	0.014	14.918	0.001
Upstream activators of mTORC1
Akt
Drug	21.744	<0.001	18.971	<0.001
Stress	47.192	<0.001	51.327	<0.001
Drug × stress	17.682	<0.001	13.422	0.002
ERK
Drug	17.581	<0.001	21.123	<0.001
Stress	14.075	0.001	25.637	<0.001
Drug × stress	21.477	<0.001	14.569	0.001

mTORC1 mammalian target of rapamycin complex 1, 4E-BP-1 eukaryotic initiation factor 4E-binding protein 1, p70S6 K p70 ribosomal protein S6 kinase, eI4FB eukaryotic translation initiation factor 4B, S6 small ribosomal protein 6, ERK extracellular signal-regulated kinase

ISSN: 1471-2202