Regions of interest | ALS | bvFTD |
---|---|---|
Grey matter | ||
Precentral gyrus (motor cortex) | Stage 1 | Pattern III |
Brainstem | ||
 Hypoglossal nucleus | Stage 1 | Pattern III |
 Precerebellar nuclei/red nucleus | Stage 2 | Pattern II |
Middle frontal gyrus | Stage 2 | Pattern II |
Cingulate—anterior | Stage 2/3 | Pattern II/III |
Postcentral gyrus (somatosensory cortex) | Stage 3 | Pattern III |
Orbitofrontal cortex | Â | Â |
 Orbital gyrus | Stage 3 | Pattern I |
 Gyrus rectus | Stage 3 | Pattern I |
Striatum | Stage 3 | Pattern II |
Hippocampal formation | Stage 4 | Pattern II |
Occipital pole | Not affected | Pattern IV |
White matter tracts | ||
Corticospinal tract | Stage 1* | Pattern III* |
Cingulum | Not affected [27] | Affected* |
Fornix | Not assessed | Affected* |
Corpus callosum | Affected* | Affected* |