Table 2 Whole brain MRI protocol parameters

a. DW-SSFP

Lines per TR

3

q value (cm⁻¹)

300

b_eff (s/mm²)

5150

TE/TR (ms)

21/28

Resolution (mm)

0.85 × 0.85 × 0.85

Flip angle (°)

24 and 94

Number of directions

120 per flip angle

Bandwidth (Hz/pixel)

393

Duration 1 volume (min:s)

5:50

Total duration (h:min:s)

24:30:00

b. Structural 3-D—Trufi

TE/TR (ms)

4.09/8.16

Resolution (mm)

0.25 × 0.25 × 0.27

Flip angle (°)

30

Phase cycling (°)

0, 90,180,270

Averages (per PC)

2

Bandwidth (Hz/pixel)

393

c. T1-map turbo spin-echo

TE/TR (ms)

14.0/1000

Resolution (mm)

1.0 × 1.0 × 1.0

Flip angle (°)

90 and 180

Averages

1

Bandwidth (Hz/pixel)

130

Inversion times (ms)

60, 120, 240, 480, 935

d. T2-map turbo spin-echo

TEs (ms)

25, 38, 50, 63, 76

TR (ms)

1000

Resolution (mm)

1.0 × 1.0 × 1.0

Flip angle (°)

90 and 180

Averages

1

Bandwidth (Hz/pixel)

130

e. Susceptibility weighted imaging multi-gradient echo

TEs (ms)

2, 8.6, 15.2, 21.8, 28.4, 35

TR (ms)

38

Resolution (mm)

0.5 × 0.5 × 0.6

Flip angle (°)

15

Number of repetitions

4

Bandwidth (Hz/pixel)

650