Fig. 4

Behavioral flexibility in App^{NL-G-F/NL-G-F} and App^NL/NL mice assessed by spatial reversal leaning task using the Barnes maze. Behavioral flexibility was assessed at 4 (a–c), 6 (d–f), and 8 (g–i) months of age by spatial reversal learning task using the Barnes maze. At all ages, App^{NL-G-F/NL-G-F} and App^NL/NL mice performed equally well in acquisition of the new target hole in comparison with WT mice, as indicated by decreases in the number of errors (a, d, and g), latency (b, e, and h), and distance (c, f, and i) across the reversal sessions. At 6 months of age, App^NL/NL mice took more time to reach the new target hole only in the first session of the reversal phase (e). 4 month-old; n = 8 WT (B6J), n = 8 App^NL/NL, n = 7 App^{NL-G-F/NL-G-F}. 6 month-old; n = 8 WT (B6J), n = 8 App^NL/NL, n = 7 App^{NL-G-F/NL-G-F}. 8 month-old; n = 8 WT (B6J), n = 7 App^NL/NL, n = 6 App^{NL-G-F/NL-G-F}