Group | MAP (mmHg) | pH | pCO2 (mmHg) | pO2 (mmHg) | SHCO3 (mmol/l) | SBE (mmol/l) | Hb. (g/dl) | Hkt. (%) | Gluc. (mg/dl) | Lactate (mmol/l) |
---|---|---|---|---|---|---|---|---|---|---|
Argatroban: baseline calibration | ||||||||||
Sham | 65.1 ± 4.2 | 7.38 ± 0.02 | 46.1 ± 2.4 | 149.0 ± 8.9 | 261 ± 0.5 | 2.5 ± 0.6 | 14.3 ± 0.2 | 43.8 ± 0.7 | 242.8 ± 20.0 | 1.9 ± 0.2 |
Vehicle | 66.3 ± 3.8 | 7.40 ± 0.02 | 45.4 ± 2.3 | 143.0 ± 7.7 | 26.9 ± 0.6 | 3.0 ± 0.6 | 14.1 ± 0.3 | 43.4 ± 0.8 | 243.4 ± 22.7 | 1.9 ± 0.3 |
Argatroban | 63.5 ± 5.7 | 7.40 ± 0.02 | 40.5 ± 2.2 | 134.8 ± 9.3 | 25.5 ± 1.0 | 1.2 ± 1.2 | 14.0 ± 0.5 | 43.0 ± 1.6 | 261.3 ± 18.3 | 1.8 ± 0.3 |
Argatroban: end of procedure | ||||||||||
Sham | 68.3 ± 4.1 | 7.29 ± 0.02 | 48.9 ± 4.9 | 112.3 ± 7.3 | 23.0 ± 1.8 | 0.9 ± 2.4 | 13.1 ± 1.0 | 40.4 ± 3.1 | 212.7 ± 61.3 | 1.4 ± 0.3 |
Vehicle | 69.0 ± 3.3 | 7.35 ± 0.06 | 41.6 ± 7.1 | 123.3 ± 2.6 | 21.6 ± 1.4 | 3.3 ± 16 | 13.0 ± 0.2 | 40.1 ± 1.6 | 224.0 ± 20.4 | 1.2 ± 0.3 |
Argatroban | 70.1 ± 4.6 | 7.33 ± 0.3 | 48.0 ± 4.8 | 124.7 ± 9.8 | 23.5 ± 1.4 | 0.5 ± 1.7 | 13.8 ± 0.4 | 42.2 ± 1.1 | 293.8 ± 28.4 | 1.7 ± 0.4 |
SCH-79797: baseline calibration | ||||||||||
Sham | 85.0 ± 1.0 | 7.38 ± 0.02 | 42.0 ± 3.0 | 137.8 ± 8.7 | 25.2 ± 1.0 | 0.6 ± 1.1 | 13.8 ± 0.4 | 42.6 ± 1.3 | 296.3 ± 15.4 | 1.8 ± 0.2 |
Vehicle | 77.7 ± 0.8 | 7.40 ± 0.02 | 43.4 ± 2.5 | 130.8 ± 11.2 | 26.9 ± 0.5 | 2.2 ± 0.8 | 13.5 ± 0.4 | 41.4 ± 1.2 | 258.4 ± 14.8 | 1.7 ± 0.4 |
SCH-1 | 76.9 ± 1.0 | 7.41 ± 0.01 | 37.7 ± 1.1 | 120.6 ± 8.1 | 25.1 ± 0.5 | 1.1 ± 0.5 | 12.3 ± 0.3 | 37.2 ± 1.1 | 306.8 ± 16.6 | 1.24 ± 0.16 |
SCH-5 | 79.9 ± 2.2 | 7.42 ± 0.01 | 39.0 ± 0.7 | 125.7 ± 7.9 | 26.5 ± 0.4 | 2.7 ± 0.6 | 12.8 ± 0.6 | 39.6 ± 2.0 | 301.2 ± 19.3 | 1.71 ± 0.3 |
SCH-79797: end of procedure | ||||||||||
Sham | 81.7 ± 1.8 | 7.414 ± 0.01 | 40.7 ± 109 | 129.7 ± 5.4 | 26.2 ± 0.6 | 2.0 ± 0.5 | 14.3 ± 0.3 | 43.8 ± 1.0 | 291.3 ± 12.7 | 1.6 ± 0.2 |
Vehicle | 75.1 ± 1.5 | 7.4 ± 0.1 | 41.1 ± 1.4 | 147.8 ± 3.7 | 25.7 ± 0.7 | 1.6 ± 0.7 | 13.1 ± 0.5 | 40.5 ± 1.4 | 250.0 ± 8.0 | 1.3 ± 0.3 |
SCH-1 | 78.2 ± 1.9 | 7.42 ± 0.01 | 36.8 ± 0.6 | 130.2 ± 4.7 | 24.6 ± 0.5 | 1.4 ± 0.4 | 12.7 ± 0.2 | 37.2 ± 1.1 | 296.8 ± 15.6 | 14 ± 0.1 |
SCH-5 | 76.9 ± 2.0 | 7.41 ± 0.02 | 37.9 ± 1.3 | 123.0 ± 6.6 | 25.3 ± 0.5 | 1.8 ± 0.5 | 12.3 ± 0.4 | 37.6 ± 1.4 | 265.4 ± 13.6 | 1.5 ± 0.2 |