Fig. 5From: Altered activity in the nucleus raphe magnus underlies cortical hyperexcitability and facilitates trigeminal nociception in a rat model of medication overuse headacheEffect of inhibiting the NRM on NTG-evoked Fos-IR in the TNC. a Photomicrograph shows patterns of c-Fos-immunoreactivity (Fos-IR) in four experimental groups (scale bar 100 µm in each section and 50 µm in the inset). b Scatterplots comparing the number of Fos-IR cells in four experimental groups. Chronic treatment with acetaminophen increased the number of nitroglycerin (NTG)-evoked Fos-IR neurons in the TNC. Microinjection of muscimol into the NRM did not alter the number of NTG-evoked Fos-IR neurons in the saline-treated vehicle-control and acetaminophen-treated ratsBack to article page