Fig. 1

The capacitance clamp. A With the original cell and the desired target capacitance (Cc, Ct), the dynamic clamp adjusts the current I_dyn to mimic the change of capacitance. B Spike trains of a cultured neuron: original at Cc = 115pF (black) and clamped at Ct = 150pF (blue). More irregular spiking suggests passing of the SNL bifurcation. C Spike shapes from B (l.) and capacitance clamp currents (r.)