Fig. 7

Effect of PNPH on lesion volume. Representative cresyl violet-stained images of coronal brain sections surrounded by embedding material from a naïve guinea pig with no surgery (a), a sham-operated guinea pig (b), and guinea pigs subjected to TBI and hemorrhagic shock (HS) followed by resuscitation with lactated Ringer’s (LR) solution (c) or PNPH (d). By 9 days of recovery from TBI, cavitation and areas of poor tissue staining typically extended through much of the cortical layers and into white matter, with sparing of the hippocampus. E, Lesion volumes of guinea pigs subjected to TBI and HS followed by resuscitation at 90 min with lactated Ringer’s solution (LR; n = 12) or PNPH (n = 12). F, Volume of the ipsilateral lateral ventricle in the naïve group (n = 6), the sham group (n = 6), and groups subjected to TBI and HS followed by resuscitation with LR or PNPH. Mean ± SD and individual data for each guinea pig are shown. **P < 0.01, ***P < 0.001 versus both naïve and sham groups