Table 2 Pathways identified as upregulated and downregulated
From: Effect of acute noise trauma on the gene expression profile of the hippocampus
Pathway name | Candidate mRNAs | P value | Q value | Pathway source |
|---|---|---|---|---|
Upregulated pathways | ||||
Cellular responses to external stimuli | 4 (MT1M, FOS, MT2A, MT1A) | 0.000181 | 0.00227 | Reactome |
Cytokine signaling in immune system | 4 (NFKBIA, FOS, MT2A, EGR1) | 0.00027 | 0.00264 | Reactome |
Immune system | 6 (NFKBIA, SLPI, EGR1, FOS, MT2A, COLEC10) | 0.000968 | 0.00452 | Reactome |
TRAF6-mediated induction of NFκB and MAP kinases upon TLR7/8 or 9 activation | 2 (NFKBIA, FOS) | 0.00197 | 0.00452 | Reactome |
Circadian entrainment | 2 (PER1, FOS) | 0.00234 | 0.00452 | KEGG |
TNF signaling pathway | 2 (EGR1, MT2A) | 0.00306 | 0.00463 | KEGG |
Relaxin signaling pathway | 2 (NFKBIA, FOS) | 0.00424 | 0.00589 | KEGG |
Apoptosis | 2 (NFKBIA, FOS) | 0.00463 | 0.00626 | KEGG |
MAPK signaling pathway | 2 (DUSP1, FOS) | 0.0205 | 0.0214 | KEGG |
Downregulated pathways | ||||
Neuronal system | 5 (SYT9, SLITRK6, SLC5A7, CHRNA3, KCNJ16) | 0.00000392 | 0.0000549 | Reactome |
SLC-mediated transmembrane transport | 4 (SLC5A7, SLC40A1, SLC5A3, SLC4A5) | 0.0000233 | 0.000152 | Reactome |
Transport of bile salts and organic acids, metal ions and amine compounds | 3 (SLC5A7, SLC40A1, SLC5A3) | 0.0000325 | 0.000152 | Reactome |
Transmission across chemical synapses | 3 (CLS5A7, KCNJ16, CHRNA3) | 0.000548 | 0.00133 | Reactome |
Signaling by type 1 insulin-like growth factor 1 receptor (IGF1R) | 2 (IGF2, KL) | 0.000666 | 0.00133 | Reactome |
Protein–protein interactions at synapses | 2 (SYT9, SLITRK6) | 0.00197 | 0.00282 | Reactome |
Longevity regulating pathway | 2 (KL, IGF2) | 0.00201 | 0.00282 | KEGG |
Cholinergic synapse | 2 (SLC5A7, CHRNA3) | 0.00317 | 0.00403 | KEGG |
Neurotransmitter receptors and postsynaptic signal transmission | 2 (KCNJ16, CHRNA3) | 0.00575 | 0.00671 | Reactome |