Fig. 7
From: N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways
The effects of PNOC overexpression on CGRP expressions and pain modulation. The administration of lentivirus or saline was performed one week prior to force application (40 g). a Temporal changes of CGRP mRNA expression in trigeminal ganglia in control lentivirus group and PNOC lentivirus group (n = 15, n = 3 for each group each day). One-way ANOVA with Bonferroni post hoc test was employed to analyze the effects of control lentivirus and PNOC overexpression lentivirus on CGRP mRNA expression. (*p < 0.05, **p < 0.01, ctrl-lenti group vs. PNOC-lenti-OE group). b Changes in PNOC expression and CGRP expression in PNOC lentivirus group exhibited high correlation (r = 0.925). c Temporal changes of RGS scores in NS group, control lentivirus group and PNOC lentivirus group (n = 8 for each group). One-way ANOVA with Bonferroni post hoc test was employed to analyze the effects of normal saline, control lentivirus and PNOC overexpression lentivirus on RGS scores. (**p < 0.01, PNOC-lenti-OE group vs. NS group, PNOC-lenti-OE group vs. ctrl-lenti group). d Difference value of orofacial pain level and N/OFQ expression level between PNOC lentivirus group and control lentivirus group. The trends of the two curves are similar and highly correlated (r = 0.994)