Fig. 3
From: NRXN1α+/- is associated with increased excitability in ASD iPSC-derived neurons
NRXN1α+/- deletions significantly alter the electrical excitability of iPSC derived neurons. A A representative evoked AP trace from a control and NRXN1α+/- neuron. Blue line indicates 0 mV baseline. B The time to reach AP firing threshold was decreased as the injected currents increased in both types of cells. C The average amplitude of evoked AP was significantly increased in NRXN1α+/- neurons. While AP rise time D showed significant increase in NRXN1α+/- neurons, AP decay time showed no significant impairment between the two groups (p = 0.07) E. Both the depolarization up slope F and repolarization down slope G were significantly increased in NRXN1α+/- neurons. Data were Mean ± SEM. Statistical significance (*p < 0.05, ***p < 0.001) were evaluated using Mann Whitney U test