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Fig. 5 | BMC Neuroscience

Fig. 5

From: Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats

Fig. 5

Sevoflurane can inhibit mitochondrial autophagy related proteins in prefrontal cortex of rats. A Representative Western blot images showing LC3B and NLRP3. LC3BI and LC3BII are LC3B subunits. The ratio of LC3BII/LC3BI represents the degree of autophagy. B–C Protein abundance statistics of LC3B and P62. Western blot images were cropped to remove irrelevant sections of the image and display only the proteins of interest. Loading control: protein extracted from prefrontal cortex tissue from sham subjects treated with saline (lane1). Tissue used for Western blot analysis was collected 24-h after the last drug-administration. These results suggested that sevoflurane reduced the degree of mitophagy in the brain. *Compared with the Ctrl group, P < 0.05; #compared with the Sev/3-MA group, P < 0.05

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BMC Neuroscience

ISSN: 1471-2202

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