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Fig. 7 | BMC Neuroscience

Fig. 7

From: Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats

Fig. 7

TEM images of the prefrontal cortex in rats. A Normal control prefrontal cortex neuron, displaying abundant organelles such as mitochondria, endoplasmic reticulum, and ribosomes. The nucleus is large and round, the density of chromatin is uniform, and nucleolus is clear. B Chromatin arrangement disorder and nucleolus disappearance (shown with star) and the mitochondrial crista was broken, and even vacuoles appeared (shown with arrow) is shown in the prefrontal cortex cells of 3-MA rats. C The mitochondria showed swelling, vacuolation and loss of crestthe mitochondrial matrix was disordered (shown with arrow) in cells of the prefrontal cortex from sevoflurane rats. D The neurons were basically normal, mitochondrial phagosomes and lysosomes were observed, and mitophagy increased (shown with triangle). Scale bar, 2000 nm

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BMC Neuroscience

ISSN: 1471-2202

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