Fig. 3From: Auditory brainstem responses are resistant to pharmacological modulation in Sprague Dawley wild-type and Neurexin1α knockout ratsAuditory brainstem responses post pharmacological treatments in Nrxn1α Sprague Dawley rats under isoflurane anesthesia. ABR waveforms across different stimulus intensities (90, 70, 50 dB) post intraperitoneal injection with diazepam (3 mg/kg) in magenta; (N = 14), gaboxadol (10 mg/kg) in teal; (N = 14), baclofen (5 mg/kg) in blue; (N = 13), bitopertin (10 mg/kg) in purple; (N = 11), retigabine (3 mg/kg) in red; (N = 16), nicotine (5 mg/kg) in yellow; (N = 14), or vehicle solution in black (0.9% saline + 0.3% Tween). Within each experimental block, dosing was counterbalanced, and applied 15 min prior to the ABR recordings for all compounds, except for in bitopertin (60 min pre-treatment time). The Black bars above the graphs indicated CBPT clusters of significant differences within subjects, i.e., between conditions. The Gray bars indicate clusters that have not reached significance threshold post-permutations. Data displayed as mean ± SEMBack to article page