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Decorrelation of low-frequency neural activity by inhibitory feedback
BMC Neuroscience volume 11, Article number: O11 (2010)
To correctly judge the functional role of cooperative neural activity it is essential to understand how neural correlations are determined by the structure and dynamics of neural networks. Shared presynaptic input is one of the major sources of correlated synaptic activity in such systems. In the asynchronous state of recurrent neural network models, however, spike correlations are considerably smaller than what one would expect based on the amount of shared presynaptic sources [1, 2]. A similar lack of correlations in the spiking activity of neighbouring cortical neurons has been observed experimentally . Recently, it has been pointed out that shared-input correlations can be actively suppressed by the dynamics of recurrent networks . Here, we show that both in networks with purely inhibitory coupling (Fig. 1A) and in those with mixed excitatory-inhibitory coupling (Fig. 1B) this active decorrelation affects mainly the activity at low frequencies (<20 Hz). High-frequency activity, in contrast, is rather unaffected. Simulations rule out that this phenomenon is the result of refractoriness. By means of a simple linear population-rate model we demonstrate that the effect is essentially explained by inhibitory feedback.
Tetzlaff T, Rotter S, Stark E, Abeles M, Aertsen A, Diesmann M: Dependence of neuronal correlations on filter characteristics and marginal spike-train statistics. Neural Comput. 2008, 20 (9): 2133-2184. 10.1162/neco.2008.05-07-525.
Kriener B, Tetzlaff T, Aertsen A, Diesmann M, Rotter S: Correlations and population dynamics in cortical networks. Neural Comput. 2008, 20 (9): 2185-2226. 10.1162/neco.2008.02-07-474.
Ecker AS, Berens P, Keliris GA, Bethge M, Logothetis NK, Tolias AS: Decorrelated Neuronal Firing in Cortical Microcircuits. Science. 2010, 327 (5965): 584-587. 10.1126/science.1179867.
Renart A, de la Rocha J, Bartho P, Hollender L, Parga N, Reyes A, Harris KD: The Asynchronous State in Cortical Circuits. Science. 2010, 327 (5965): 587-590. 10.1126/science.1179850.
Supported by the Research Council of Norway (eVITA, Notur), the Helmholtz Alliance on Systems Biology, the Next-Generation Supercomputer Project of MEXT, EU Grant 15879 (FACETS), DIP F1.2, and BMBF Grant 01GQ0420 to BCCN Freiburg. All network simulations were carried out using NEST (http://www.nest-initiative.org).
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Tetzlaff, T., Helias, M., Einevoll, G.T. et al. Decorrelation of low-frequency neural activity by inhibitory feedback. BMC Neurosci 11, O11 (2010) doi:10.1186/1471-2202-11-S1-O11
- Neural Network
- Network Model
- Functional Role
- Cortical Neuron
- Neural Activity