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- Open Access
Evaluation of functional arterial spin labeling data using a perfusion template
© Petr et al; licensee BioMed Central Ltd. 2011
- Published: 18 July 2011
- Arterial Spin Label
- Partial Volume Correction
- Supplementary Motor Cortex
- Large Activation Region
- Interpolation Artifact
ASL allows non-invasive imaging and quantification of brain perfusion by magnetically labeling blood in the brain-feeding arteries. In this study, a template created from perfusion images of 25 resting healthy subjects was used to automatically detect hyper perfusion patterns of 8 other subjects. DARTEL registration was used to improve the precision of the template and partial volume correction to prevent interpolation artifacts.
This study shows that a perfusion template can be used to assess task-related activation zones in functional ASL data while using only activated phase. Two assumptions can be made to explain why standard functional analysis yields slightly larger activation regions. First, the use of FWHM 6mm Gaussian kernel possibly enlarges the detected zones. Second, the data analyzed using SPM contains both resting and activated phases whereas only the activated phase was compared to the template. Future work will focus on detection of hyperperfusion in different neurodegenerative diseases taking into account registration issues of pathological T1 images.
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