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Mechanisms of pathological synchrony in Parkinson's disease induced by changes in synaptic and cellular properties due to dopamine
BMC Neuroscience volume 13, Article number: P54 (2012)
Synchronized oscillations between neurons or across nuclei within parkinsonian basal ganglia (BG) have been extensively reported over past decade. They are implied in the hypokinetic motor symptoms of Parkinson’s disease . Thus, it is crucial to understand the mechanisms underlying the observed abnormally synchronous rhythms. Previous experimental studies have indicated that two nuclei within BG, subthalamic nucleus (STN) and external globus Pallidus (GPe), may comprise key substrates in the maintenance of the pathological synchronous rhythms in parkinsonian BG. Modeling studies also demonstrated that STN-GPe network has an ability to generate various rhythms due to the reciprocal inhibitory-excitatory connections . Although other structures may also play important roles, recent modeling work  suggests that STN-GPe network are able to exhibit characteristic intermittent temporal patterns of synchrony observed in experimental recordings from parkinsonian patients .
Dopamine loss, a characteristic feature of Parkinson’s disease generally accepted to cause motor symptoms, is known to affect network properties as well cellular properties of STN-GPe network. In this study, we considered how these changes due to dopamine loss contribute to the generation of pathological rhythms in STN-GPe network. We reduced large STN-GPe network model  (each nuclei consist of several model neurons described by experimentally-based conductance-based equations) to two simplified models. First one is a network consisting of two inhibitory bursting cells with self-inhibition and the second one is GPe neuron with the periodic STN synaptic input. The dynamics of and bifurcations in the models were studied by computational and analytical techniques.
There is an experimental evidence for how dopamine presynaptically suppresses different types of basal ganglia synapses. We show how the chance in strength of dopamine-modulated synapses promotes intermittent synchronous activity patterns under very general conditions and investigate the cellular properties, necessary for this dynamics. It is also known that dopamine affects not only synaptic properties, but also cellular properties of BG neurons. In particular, change in the dopaminergic status leads to change in the temporal features of firing patterns of STN neuron. So we also considered how dopamine-dependent features of STN neuron firing modulate the GPe response and the synchrony between STN input and GPe output. As STN dopaminergic modulation and STN activity pattern vary, we observe the overall transition from low coherence state to high coherence state through intermittent synchronous activity. This points to the important role of GPe cells within BG circuit and demonstrate that the response of GPe cell, which was achieved through the interaction between the intrinsic properties of the cell itself and membrane properties of STN cell, provide good source for the temporal characteristics of synchrony observed in experimental setting.
In sum, our modeling studies explain how the lack of dopamine in Parkinson’s disease may lead to the generation of intermittent synchronous dynamics in the basal ganglia via two different pathways: cellular and synaptic.
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This study was supported by NIH grant R01NS067200 (NSF/NIH CRCNS program).
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Park, C., Rubchinsky, L.L. Mechanisms of pathological synchrony in Parkinson's disease induced by changes in synaptic and cellular properties due to dopamine. BMC Neurosci 13, P54 (2012) doi:10.1186/1471-2202-13-S1-P54
- Cellular Property
- Coherence State
- Basal Ganglion Circuit
- Dopamine Loss
- Basal Ganglion Neuron